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Poly(ADP-ribose) Polymerase [PARP] / Related Products
You are here: Product Lines > DNA Regulation / Transcription > Poly(ADP-ribose) Polymerase [PARP] / Related Products
 
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ALX-270-418 Revised 16-Jun-08
Gallotannin
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SYNONYMS Tannic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-270-418-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C76H52O46
MW: 1701.2
CAS NUMBER: 1401-55-4
MERCK INDEX: 14: 9052
RTECS: WW5075000
SOURCE/HOST: Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.
PURITY: >95%
APPEARANCE: Beige to light brown powder.
SOLUBILITY: Soluble in water, 100% ethanol, acetone or warm glycerol.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.
Product Specific Literature References
Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995) Abstract
The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000) Abstract
Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000) Abstract
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004) Abstract
Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005) Abstract
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Further Categories Containing This Product:
PARG / Related Products • Free Radical Scavengers • NOS Inhibitors (NOS Induction & Enzyme Activity) • Phenolic Acids • Natural Products - Nitric Oxide Pathway Modulators • DNA Repair Other Products
 
 
ALX-190-001 Revised 20-Jun-08
H-Trp-Glu-OH
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SYNONYMS H-WE-OH
G3335
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-190-001-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C16H19N3O5
MW: 333.3
CAS NUMBER: 36099-95-3
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Cell permeable, selective and reversible PPARγ antagonist. Has been shown to inhibit the agonist activity of rosiglitazone (Prod. No. ALX-350-125) in a dose-dependent manner (IC50=31.9µM).
Product Specific Literature References
The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation: F. Ye, et al.; Chembiochem. 7, 74 (2006) Abstract
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator activated receptors: N. B. Mettu, et al.; Mol. Endocrinol. 21, 2361 (2007) Abstract; Full Text
 
 
ALX-270-279 Revised 20-Oct-08
4-Hydroxyquinazoline
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SYNONYMS 4-Quinazolinol
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-279-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C8H6N2O
MW: 146.2
CAS NUMBER: 491-36-1
RTECS: VA2300000
PURITY: ≥98%
APPEARANCE: White to grey solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-270-278 Revised 01-Jul-08
5-Iodo-6-amino-1,2-benzopyrone
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SYNONYMS INH2BP
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-278-M001   1 mg 25.00 USD Add To Cart
ALX-270-278-M005   5 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C9H6INO2
MW: 287.1
CAS NUMBER: 137881-27-7
PURITY: ≥98%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Packaged under inert gas.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase: P.I. Bauer, et al.; Biochimie 77, 374 (1995) Abstract
Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development: M. Endres, et al.; Eur. J. Pharmacol. 351, 377 (1998) Abstract
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells: M. Kennedy, et al.; Gastroenterology 114, 510 (1998) Abstract
Potential role of the peroxynitrate-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock: C. Szabó, et al.; Shock 9, 341 (1998) Abstract
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase: C. Szabó, et al.; PNAS 95, 3867 (1998) Abstract; Full Text
Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation: L. Virág, et al.; Free Radic. Biol. Med. 25, 1075 (1998) Abstract
Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death: L. Virág, et al.; J. Immunol. 161, 3753 (1998) Abstract; Full Text
Novel roles of nitric oxide in hemorrhagic shock: C. Szabo & T.R. Billiar; Shock 12, 1 (1999) Abstract
Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME): E. Kirsten & E. Kun; Int. J. Mol. Med. 5, 279 (2000) Abstract
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis: G.S. Scott, et al.; J. Neuroimmunol. 117, 78 (2001) Abstract
Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes: J.G. Mabley, et al.; Br. J. Pharmacol. 133, 909 (2001) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-480-039 Revised 20-Oct-08
1,5-Isoquinolinediol
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SYNONYMS 5-Hydroxy-1(2H)-isoquinolinone
1,5-Dihydroxyisoquinoline
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-480-039-M005   5 mg 20.00 USD Add To Cart
ALX-480-039-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C9H7NO2
MW: 161.2
CAS NUMBER: 5154-02-9
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 0.1N NaOH, methanol or in DMSO; insoluble in water and 0.1N HCl.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description

Potent inhibitor of inducible nitric oxide synthase (iNOS; NOS II) in mouse macropaghes. Potently blocks poly(ADP-ribose) polymerase-1 (PARP-1). Neuroprotectant.
Product Specific Literature References
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994) Abstract
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 128, 1339 (1999) Abstract
All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor: D.M. Berry, et al.; Leuk. Res. 24, 307 (2000) Abstract
Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006) Abstract
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • DNA Repair Other Products
 
 
ALX-270-450 Revised 08-Jan-07
3-Methyl-5-AIQ . hydrochloride
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SYNONYMS 3-Methyl-5-aminoisoquinolinone . HCl
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-450-M001   1 mg 50.00 USD Add To Cart
ALX-270-450-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C10H10N2O . HCl
MW: 174.2 . 36.4
PURITY: ≥98% (NMR)
APPEARANCE: Light brown solid.
SOLUBILITY: Soluble in water or DMSO; poorly soluble in 100% ethanol or methanol; insoluble in dichloromethane or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
IDENTITY: Identity determined by IR, 1H-NMR, 13C-NMR.

Product Description
Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50=0.23µM) in vitro. Exhibits outstanding therapeutic benefits in models of myocardial infarction, ischaemia-reperfusion of the liver and kidney, heart transplantation and acute lung inflammation.
Product Specific Literature References
Synthesis and PARP-1 inhibitory activity of 3-substituted analogues of the potent water-soluble PARP inihbitor 5-aminoisoquinolin-1-one (5-AIQ): E. C. Y. Woon, et al.; Bioorg. Med. Chem. (submitted), (2006)
 
 
ALX-380-109 Revised 01-Jul-08
Minocycline . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
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ALX-380-109-M050   50 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C23H27N3O7 . HCl
MW: 457.5 . 36.5
CAS NUMBER: 13614-98-7
MERCK INDEX: 14: 6202
RTECS: QI7630500
SOURCE/HOST: Semi-synthetic
APPEARANCE: Yellow crystalline solid.
SOLUBILITY: Soluble in water (50mg/ml, warm) or DMSO (7mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Tetracycline derivative with antimicrobial activity. Inhibitor of angiogenesis, apoptosis and poly(ADP-ribose) polymerase-1 (PARP-1). Anti-inflammatory and neuroprotective.
Product Specific Literature References
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma: J.L. Frazier, et al.; J. Neurooncol. 64, 203 (2003) Abstract
Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases: J.S. Yao, et al.; Circ. Res. 95, 364 (2004) Abstract
Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria: J. Wang, et al.; J. Biol. Chem. 279, 19948 (2004) Abstract
Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis: M. Castanares, et al.; BBRC 337, 663 (2005) Abstract
Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy: J.K. Krady, et al.; Diabetes 54, 1559 (2005) Abstract
Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations: C.C. Alano, et al.; PNAS 103, 9685 (2006) Abstract
Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation: K. Maier, et al.; Neurobiol. Dis. 25, 514 (2007) Abstract
Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration: J.S. Yao, et al.; Neurochem. Int. 50, 524 (2007) Abstract
Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia: Y. Levkovitz, et al.; Brain Res. 1154, 154 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Nitric Oxide Pathway Modulators • NOS Inhibitors (NOS Induction & Enzyme Activity) • Antibiotics for Inflammation Research • Antibiotics - Apoptosis Inducers & Inhibitors • Neuroactive Agents Other Products • COX Inhibitors • PARP Inhibitors
 
 
ALX-201-286 Revised 18-Dec-08
Minor Vault p193 Protein (human) (recombinant) (His)
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SYNONYMS VPARP (human) (recombinant) (His)
PARP-4 (human) (recombinant) (His)
PRODUCT LINE Cancer
PRODUCT CATEGORY Minor Vault Protein p193 / Related Products
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ALX-201-286-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 2.4.2.30
SOURCE/HOST: Produced in E. coli. Catalytic domain of human minor vault p193 protein (aa 220-574) is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.2mg/ml
PURITY: ≥98%
FORMULATION: Liquid. In PBS containing 50% glycerol.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs): H. Otto, et al.; BMC Genomics 6, 139 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UKK3: PARP4 (human)
General Literature References
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase: V.A. Kickhoefer, et al.; J. Cell Biol. 146, 917 (1999) Abstract; Full Text
Further Categories Containing This Product:
PARP Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-802-020 Revised 01-Jul-08
Monoclonal Antibody to ART1 (human) (GUGU1-A3)
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SYNONYMS anti-ecto-ADP-ribosyltransferase 1 (human) MAb (GUGU1-A3)
anti-CD296 (human) MAb (GUGU1-A3)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
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ALX-802-020-L001   1 ml 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: GUGU1-A3
ISOTYPE: Rat IgG2b
FORMULATION: Liquid. Hybridoma supernatant containing 0.02% sodium azide.
IMMUNOGEN: Vector containing the cDNA of human ART1 (ecto-ADP-ribosyltransferase 1; CD296).
SPECIFICITY: Recognizes human ART1.
APPLICATION: Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation: F. Koch-Nolte, et al.; Cell. Immunol. 236, 66 (2005) Abstract
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003), (Review) Abstract; Full Text
Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling

: M. Seman, et al.; Curr. Med. Chem. 11, 857 (2004), (Review) Abstract
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells: F. Koch-Nolte, et al.; Ann. Med. 38, 188 (2006), (Review) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-802-028 Revised 01-Jul-08
Monoclonal Antibody to ART1 (mouse) (NOGU1-A111)
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SYNONYMS anti-ecto-ADP-ribosyltransferase 1 (mouse) MAb (NOGU1-A111)
anti-CD296 (mouse) MAb (NOGU1-A111)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
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ALX-802-028-L001   1 ml 330.00 USD Add To Cart
Product Specification