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ALX-350-270 Revised 08-Feb-08
α-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
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ALX-350-270-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C39H54N10O14S
MW: 919.0
CAS NUMBER: 23109-05-9
MERCK INDEX: 14: 373
RTECS: BD6195000
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in 100% ethanol (5mg/ml), DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits eukaryotic RNA-polymerase II with high efficiency, but not eukaryotic RNA-polymerase I, or bacterial or viral RNA-polymerases. Inhibits mammalian protein synthesis.
Product Specific Literature References
Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver: F. Stirpe & L. Fiume; Biochem. J. 103, 67P (1967) Abstract
Specific inhibition of nuclear RNA polymerase II by alpha-amanitin: T.J. Lindell, et al.; Science 170, 447 (1970) Abstract
Fifty years of amanitin: T. Wieland & H. Faulstich; Experientia 47, 1189 (1991), (Review) Abstract
Alpha-amanitin blocks translocation by human RNA polymerase II: X.Q. Gong, et al.; J. Biol. Chem. 279, 27422 (2004) Abstract
Further Categories Containing This Product:
Amanitins & Phalloidins/Related Products • RNA Polymerases/Related Products • Protein Synthesis Other Products
 
 
ALX-350-271 Revised 08-Oct-07
β-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
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ALX-350-271-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C39H53N9O15S
MW: 920.0
CAS NUMBER: 21150-22-1
MERCK INDEX: 14: 373
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
FORMULATION: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Biological activity like α-amanitin (Prod. No. ALX-350-270), but contains a carboxy group which is useful for coupling reactions.
Further Categories Containing This Product:
Amanitins & Phalloidins/Related Products • RNA Polymerases/Related Products • Protein Synthesis Other Products
 
 
ALX-350-272 Revised 17-Dec-07
γ-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation/Transcription
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ALX-350-272-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C39H54N10O13S
MW: 903.0
CAS NUMBER: 13567-11-8; 21150-23-2
MERCK INDEX: 14: 373
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Biological activity like α-amanitin (Prod. No. ALX-350-270).
Further Categories Containing This Product:
Amanitins & Phalloidins/Related Products • RNA Polymerases/Related Products • Protein Synthesis Other Products
 
 
ALX-350-149 Revised 23-Oct-07
Cylindrospermopsin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-149-C025   25 µg 140.00 USD Add To Cart
ALX-350-149-C100   100 µg 210.00 USD Add To Cart
Product Specification
FORMULA: C15H21N5O7S
MW: 415.4
CAS NUMBER: 143545-90-8
RTECS: UV9104310
SOURCE/HOST: Isolated from Cylindrospermopsis raciborskii.
PURITY: ≥95% (HPLC)
APPEARANCE: Glassy solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC. HIGHLY IRRITANT.

Product Description
Tricyclic alkaloid hepatotoxin. Exhibits a completely different mechanism of toxicity than microcystins. Protein synthesis inhibitor. Might be carcinogenic. Inhibits pyrimidine nucleotide synthesis.
Product Specific Literature References
Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir: P.R. Hawkins, et al.; Appl. Environ. Microbiol. 50, 1292 (1985) Abstract; Full Text
Cylindrospermopsin, a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii: I. Ohtani, et al.; JACS 114, 7941 (1992) Full Text
Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake: P.R. Hawkins, et al.; Toxicon. 35, 341 (1997) Abstract
Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity: G.R. Shaw, et al.; Ther. Drug Monit. 22, 89 (2000) Abstract
Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin: I.R. Falconer & A.R. Humpage; Environ. Toxicol. 16, 192 (2001) Abstract
The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin: D.J. Griffiths and M.L. Saker; Environ. Toxicol. 18, 78 (2003), Review Abstract
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice: M. Reisner, et al.; Toxicol. Sci. 82, 620 (2004) Abstract
Further Categories Containing This Product:
Uridine Derivatives Other Products • Alkaloids • Lipid Metabolism Other Products • Protein Synthesis Other Products
 
 
ALX-380-011 Revised 01-Oct-07
Fusidic acid . sodium salt
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Nitric Oxide Pathway Modulators
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ALX-380-011-M050   50 mg 15.00 USD Add To Cart
Product Specification
FORMULA: C31H47O6 . Na
MW: 515.7 . 23.0
CAS NUMBER: 751-94-0
MERCK INDEX: 14: 4317
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Antibiotic which suppresses nitric oxide (NO) toxicity in pancreatic islet cells. Inhibits protein synthesis by inhibition of elongation factor G at the level of the ribosome.
Product Specific Literature References
Fusidic acid: a new antibiotic: W.O. Godtfredsen, et al.; Nature 193, 987 (1962) Abstract
Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics: N. Tanaka, et al.; BBRC 30, 278 (1968) Abstract
On the Mode of Action of Fusidic Acid: C.L. Harvey, et al.; Biochemistry 5, 3320 (1969)
Fusidic acid suppresses nitric oxide toxicity in pancreatic islet cells: V. Burkart, et al.; Biochem. Pharmacol. 48, 1379 (1994) Abstract
Fusidic acid in vitro activity: P. Collignon and J. Turnidge; Int. J. Antimicrob. Agents 12, S45 (1999), Review Abstract
Fusidic acid non-antibacterial activity: K. Christiansen; Int J Antimicrob Agents 12, S73 (1999), Review Abstract
Dumb and dumber--the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus
: B.P. Howden & M.L. Grayson; Clin. Infect. Dis. 42, 394 (2006), Review Abstract
Further Categories Containing This Product:
Protein Synthesis Other Products
 
 
ALX-380-059 Revised 16-Oct-07
Hygromycin B (liquid)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antiviral/Anti-HIV
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ALX-380-059-UM01   1 MU 94.00 USD Add To Cart
Product Specification
FORMULA: C20H37N3O13
MW: 527.5
CAS NUMBER: 31282-04-9
MERCK INDEX: 14: 4852
SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
QUANTITY: 1MU (1 million units) in 2.15ml. 350-450mg hygromycin B/ml.
PURITY: ≥80%
APPEARANCE: Dark brown solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Sterile and ready-to-use antibiotic with high activity. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.
Product Specific Literature References
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus: R. L. Mann & W. W. Bromer; J. Am. Chem. Soc. 80, 2714 (1958)
Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells: J. C. Lacal & L. Carrasco; Antimicrob. Agents Chemother. 24, 273 (1983) Abstract
Induction of p53-independent apoptosis by hygromycin B: suppression by Bcl-2 and adenovirus E1B 19-kDa protein: G. Chen, et al.; Exp. Cell Res. 221, 55 (1995) Abstract
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit:: D.E. Brodersen, et al.; Cell 103, 1143 (2000) Abstract
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes: M. C. Ganoza & M. C. Kiel; Antimicrob. Agents Chemother. 45, 2813 (2001) Abstract
Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli: S. M. McGaha & W. S. Champney; Antimicrob. Agents Chemother. 51, 591 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Microbiological assay: 350'000-500'000U/ml.
Further Categories Containing This Product:
Protein Synthesis Other Products
 
 
ALX-380-093 Revised 16-Jun-08
Novobiocin . sodium salt
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SYNONYMS Albamycin
Streptonivicin
N-[7-[[3-O-Aminocarbonyl-6-deoxy-5-C-methyl-4-O-β-L-lyxo-hexapyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl)benzamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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ALX-380-093-G001   1 g 30.00 USD Add To Cart
Product Specification
FORMULA: C31H35N2O11 . Na
MW: 611.6 . 23.0
CAS NUMBER: 1476-53-5
MERCK INDEX: 14: 6722
RTECS: RD5425000
PURITY: ≥95%
APPEARANCE: White to pale yellow solid.
SOLUBILITY: Soluble in water (100mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: HARMFUL. IRRITANT.

Product Description
Antibiotic. Inhibitor of HSP90. Interacts with the C-terminal ATP-binding domain of HSP90 in contrast to the benzoquinone ansamycins 17-AAG (Prod. No. ALX-380-091), geldanamycin (Prod. No. ALX-380-054), herbimycin A (Prod. No. ALX-350-029), and the chemically unrelated radicicol (Prod. No. ALX-380-092), which bind to the N-terminal ATP-binding site of HSP90. Inhibitor of DNA gyrase. Useful for the production of positively supercoiled plasma DNA, targeting the nucleotide-binding site of gyrase B. Inhibits retrovirus RNA-dependent DNA polymerase. Potent inhibitor of ADP ribosylation. Inhibits LPS-induced production of pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6 and IL-10. Inhibits protein synthesis and alters the phosphorylation state of several cytosolic proteins. Reverses etoposide resistance in non-P-glycoprotein expressing multidrug resistant (MDR) tumor cell lines. Inducer of CD38 on cells of the myelomonocytic  lineage. Forms ion channels in lipid bilayers.
Product Specific Literature References
Novobiocin-a specific inhibitor of semiconservative DNA replication in permeabilized Escherichia coli cells: W.L. Staudenbauer; J. Mol. Biol. 96, 201 (1975) Abstract
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase: M. Gellert, et al.; PNAS 73, 4474 (1976) Abstract; Full Text
Energy coupling in DNA gyrase and the mechanism of action of novobiocin: A. Sugino, et al.; PNAS 75, 4838 (1978) Abstract; Full Text
Effect of novobiocin and other DNA gyrase inhibitors on virus replication and DNA synthesis in herpes simplex virus type 1-infected BHK cells: B. Francke and J. Margolin; J. Gen. Virol. 52, 401 (1981) Abstract; Full Text
Inhibition of retrovirus RNA-dependent DNA polymerase by novobiocin and nalidixic acid: Y. Sumiyoshi, et al.; J. Gen. Virol. 64, 2329 (1983) Abstract
Positively supercoiled plasmid DNA is produced by treatment of Escherichia coli with DNA gyrase inhibitors: D. Lockshon and D.R. Morris; Nucleic Acids Res. 11, 2999 (1983) Abstract
Structure-activity relationships in DNA gyrase inhibitors: S. Radl; Pharmacol. Ther. 48, 1 (1990), (Review) Abstract
Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin: G. Rappa, et al.; Cancer Res. 53, 58487 (1993) Abstract
The properties of ion channels formed by the coumarin antibiotic, novobiocin, in lipid bilayers: A.M. Feigin, et al.; Biochim. Biophys. Acta 1234, 43 (1995) Abstract
Mechanism of inhibition of vaccinia DNA topoisomerase by novobiocin and coumermycin: J. Sekiguchi, et al.; J. Biol. Chem. 271, 2313 (1996) Abstract; Full Text
Immunomodulating properties of the antibiotic novobiocin in human monocytes: A. Luhrmann, et al.; Antimicrob. Agents Chemother. 42, 1911 (1998) Abstract; Full Text
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins: M.G. Marcu, et al.; J. Natl. Cancer Inst. 92, 242 (2000) Abstract
The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone: M.G. Marcu, et al.; J. Biol. Chem. 275, 37181 (2000) Abstract; Full Text
Novobiocin is a novel inducer of CD38 on cells of the myelomonocytic lineage: A. Thiele, et al.; Biochim. Biophys. Acta 1542, 32 (2002) Abstract
Evidence that the novobiocin-sensitive ATP-binding site of the heat shock protein 90 (hsp90) is necessary for its autophosphorylation: T. Langer, et al.; Cell Biol. Int. 26, 653 (2002) Abstract
Alteration of Escherichia coli topoisomerase IV to novobiocin resistance: C.D. Hardy and N.R. Cozzarelli; Antimicrob. Agents Chemother. 47, 941 (2003) Abstract; Full Text
Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance: C.H. Gross, et al.; Antimicrob. Agents Chemother. 47, 1037 (2003) Abstract; Full Text
A coumermycin/novobiocin-regulated gene expression system: H.F. Zhao, et al.; Hum. Gene Ther. 14, 1619 (2003) Abstract
Destabilization of the non-pathogenic, cellular prion-protein by a small molecular drug: H.J. Ochel and G. Gademann; Antivir. Ther. 9, 441 (2004) Abstract
Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions: B.G. Yun, et al.; Biochemistry 43, 8217 (2004) Abstract
Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90: J.A. Burlison, et al.; JACS 128, 15529 (2006) Abstract
Further Categories Containing This Product:
Protein Synthesis Other Products • HSP90/HtpG/Related Products • Antibiotics - Topoisomerase Inhibitors • Anti-inflammatory Agents Other Products
 
 
ALX-430-158 Revised 03-Apr-08 New product
PTC124
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SYNONYMS 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]-benzoic acid
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Protein Synthesis Other Products
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ALX-430-158-M002   2 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C15H9FN2O3
MW: 284.2
CAS NUMBER: 775304-57-9
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Orally bioavailable 284 D-1,2,4-oxadiazole. Promotes readthrough of premature translation termination codons. Targets genetic disorders caused by nonsense mutations. Shows no concomitant effects on normal termination or mRNA decay.
Product Specific Literature References
PTC124 targets genetic disorders caused by nonsense mutations: E.M. Welch, et al.; Nature 447, 87 (2007) Abstract
PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model: M. Du, et al.; PNAS 105, 2064 (2008) Abstract
 
 
ALX-380-261 Revised 04-Feb-08
Thiostrepton
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-261-G001   1 g 80.00 USD Add To Cart
ALX-380-261-G005   5 g 320.00 USD Add To Cart
Product Specification
FORMULA: C72H85N19O18S5
MW: 1664.9
CAS NUMBER: 1393-48-2
MERCK INDEX: 14: 9364
RTECS: XN6300100
SOURCE/HOST: Isolated from Streptomyces azureus.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetic acid, DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.

Product Description
Thiazole-containing peptide antibiotic. Inhibits protein synthesis by preventing binding of GTP to the 50S ribosomal subunit. Inhibits binding of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome.
Product Specific Literature References
Studies on translocation. VI. Thiostrepton prevents the formation of a ribosome-G factor-guanine nucleotide complex: J.W. Bodley, et al.; BBRC 41, 1406 (1970) Abstract
Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA: U.R. Kutay, et al.; Biochim. Biophys. Acta 1050, 193 (1990) Abstract
Alpha-sarcin cleavage of ribosomal RNA is inhibited by the binding of elongation factor G or thiostrepton to the ribosome: S.P. Miller & J.W. Bodley; Nucl. Acids Res. 19, 1657 (1991) Abstract; Full Text
Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton: P.C. Ryan, et al.; J. Mol. Biol. 221, 1257 (1991) Abstract
Characterization of an 8.7-kilobase thiostrepton resistance-encoding plasmid (pGIF3) of Streptomyces incarnatus: H. Malina & M. Robert-Gero; Appl. Environ. Microbiol. 58, 895 (1992) Abstract; Full Text
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A: G. Rosendahl & S. Douthwaite; Nucl. Acids Res. 22, 357 (1994) Abstract; Full Text
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome: M.V. Rodnina, et al.; PNAS 96, 9586 (199