Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
> DNA Regulation / Transcription
Antibiotics - DNA Regulation / Transcription
DNA Metabolism
DNA Fragmentation, Damage & Repair
Helicases / Related Products
Histones & Histone Modification
Natural Products - DNA Regulation / Transcription
Nuclear Envelope & Nuclear Transport
Nuclear Receptors / Related Products
Nucleotides / Related Products
Poly(ADP-ribose) Polymerase [PARP] / Related Products
RNA Polymerases / Related Products
Transcription Factors / Related Products
Transcription Inhibitors / Related Products
Transcription Regulators / Related Products
Translation Inhibitors
Zinc Finger Proteins / Related Products
DNA Regulation / Transcription Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
200-250
of 696
Page 5
of 14
Select Page:
<<
1
2
3
4
5
6
7
8
9
10
>>
ALX-850-326
Revised 07-Jan-08
HAT Activity Assay Kit
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-326-KI01
1 Kit
413.00 USD
Product Specification
QUANTITY:
~100 tests.
KIT/SET CONTAINS:
2x HAT Assay Buffer
HAT Substrate I
HAT Substrate II
NADH Generating Enzyme
NE (Nuclear Extract 4 mg/ml)
HAT Reconstitution Buffer
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
Product Images
Please click on thumbnails to enlarge.
Product Description
Histone acetyltransferases (HATs) have been implicated to play a crucial role in various cellular functions, such as gene transcription, differentiation, and proliferation. HAT Activity Colorimetric Assay Kit offers a convenient, nonradioactive system for a rapid and sensitive detection of HAT activity in mammalian samples. The kit utilizes active recombinant HAT as a positive control and acetyl-CoA as a cofactor. Acetylation of peptide substrate by active HAT releases the free form of CoA which then serves as an essential coenzyme for producing NADH. NADH can easily be detected spectrophotometrically upon reacting with a soluble tetrazolium dye. The detection can be continuous and suitable for kinetic studies. The kit provides a simple, straightforward protocol for a complete assay.
Product Specific Literature References
Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells:
P.A. Ruiz, et al.; J. Nutr.
137
, 1208 (2007)
Abstract
General Information
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Activity Assays
ALX-630-102
Revised 05-Apr-08
HC Toxin
SYNONYMS
Cyclo-(D-Pro-L-Ala-D-Ala-L-2-amino-8-oxo-9,10-epoxydecanoic acid)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-630-102-M001
1 mg
195.00 USD
Product Specification
FORMULA:
C
21
H
32
N
4
O
6
MW:
436.5
CAS NUMBER:
83209-65-8
SOURCE/HOST:
Isolated from
Helminthosporium carbonium
.
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable as supplied for up to 1 year. Stock solutions are stable for up to 3 months when stored at -20°C
HAZARD:
TOXIC.
Product Description
Potent, cell permeable, non-competitive and reversible inhibitor of histone deacetylase (HDAC) (IC
50
=30nM). Does not inhibit histone acetyltransferases. Induces expression of γ-globulin in erythroid cells. Shows anti-mitogenic activities. Induces cell cycle arrest and apoptosis in tumor cells.
Product Specific Literature References
The structure and conformation of HC-toxin:
M. Kawai, et al.; Biochem. Biophys. Res. Commun.
111
, 398 (1983)
Abstract
Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum:
G. Brosch, et al.; Plant Cell
7
, 1941 (1995)
Abstract
Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells:
K.N. Min, et al.; Arch. Pharm. Res.
27
, 554 (2004)
Abstract
Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells:
K.E. Joung, et al.; Arch. Pharm. Res.
27
, 640 (2004)
Abstract
Further Categories Containing This Product:
HDAC Inhibitors
•
Natural Products for Cell Cycle Research
•
Cell Cycle Blockers & Inhibitors / Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-350-120
Revised 01-Apr-08
Helenalin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-120-MC05
0.5 mg
240.00 USD
Product Specification
FORMULA:
C
15
H
18
O
4
MW:
262.3
CAS NUMBER:
6754-13-8
SOURCE/HOST:
Isolated from
Arnica chamissonis.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (10mg/ml) or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Potent anti-inflammatory and antineoplastic agent. Induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-X
L
or Bcl-2 are overexpressed. Also an inhibitor of NF-κB.
Product Specific Literature References
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB
:
G. Lyss, et al.; J. Biol. Chem.
378
, 951 (1997)
Abstract
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65:
G. Lyss, et al; J. Biol. Chem.
273
, 33508 (1998)
Abstract
Constituents of Helenium species.XIII. The structure of Helenalin and Mexicanin A
:
W. Herz, et al.; JACS
85
, 19 (1963)
Further Categories Containing This Product:
Bcl-2 Family Modulators
•
NF-kB Pathway Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - NF-kB Pathway Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
ALX-350-303
Revised 12-Feb-07
Heraclenin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Apoptosis Inducers & Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-303-M002
2 mg
70.00 USD
Product Specification
FORMULA:
C
16
H
14
O
5
MW:
286.3
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in methanol or water. Almonst insoluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
The furanocoumarins heraclenin (Prod. No.
ALX-350-303
) and imperatorin (Prod. No.
ALX-350-302
) inhibit T cell-receptor-mediated proliferation in human primary T cells in a concentration-dependent manner. Both compounds also induce apoptosis. While imperatorin induces DNA fragmentation at the G1/S phase of the cell cycle, heraclenin induces DNA fragmentation at the G2/M phases of the cell cycle, thus despite a close structural similarity they induce apoptosis in mechanistically different ways.
Product Specific Literature References
Coumarins from Opopanax chironium. New dihydrofuranocoumarins and differential induction of apoptosis by imperatorin and heraclenin:
G. Appendino, et al.; J. Nat. Prod.
67
, 532 (2004)
Abstract
Imperatorin inhibits T-cell proliferation by targeting the transcription factor NFAT:
N. Marquez, et al.; Planta Med.
70
, 1016 (2004)
Abstract
Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway:
R. Sancho, et al.; J. Biol. Chem.
279
, 37349 (2004)
Abstract
;
Full Text
Related Products
ALX-350-302
Imperatorin
Further Categories Containing This Product:
DNA Fragmentation & Chromatin Condensation
ALX-385-011
Revised 05-Apr-08
(±)-Hesperetin
SYNONYMS
(±)-3',5,7-Trihydroxy-4'-methoxyflavanone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavonoids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-385-011-G001
1 g
21.00 USD
Product Specification
FORMULA:
C
16
H
14
O
6
MW:
302.3
CAS NUMBER:
520-33-2
MERCK INDEX:
14:
4670
PURITY:
≥95% (HPLC)
APPEARANCE:
Off-white to yellow powder.
SOLUBILITY:
Soluble in 100% ethanol; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. Suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids:
C.A. Rice-Evans, et al.; Free Radical Biol. & Med.
20
, 933 (1996), (Review)
Abstract
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats:
H. K. Kim, et al.; Clin. Chim. Acta
327
, 129 (2003)
Abstract
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin:
J. Cho; Arch. Pharm. Res.
29
, 699 (2006)
Abstract
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin:
J. Y. Kim, et al.; Aging Cell
5
, 401 (2006)
Abstract
Hesperetin Induced G1-Phase Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells: Involvement of CDK4 and p21:
E.J. Choi; Nutr. Cancer
59
, 115 (2007)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
•
Active Substances from Fruit and Vegetables
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Antioxidants
ALX-340-037
Revised 08-Jul-08
8(S)-HETE
SYNONYMS
8-Hydroxy-[S-(E,Z,Z,Z)]-5,9,11,14-eicosatetraenoic acid
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hydroxy, Hydroperoxy & Oxo Fatty Acids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-037-C025
25 µg
165.00 USD
Product Specification
FORMULA:
C
20
H
32
O
3
MW:
320.5
CAS NUMBER:
98462-03-4
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na
2
CO
3
(2mg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:
Protect from light and oxygen.
Product Description
Activator of PPARα. Activates mouse skin protein kinase C (PKC).
Product Specific Literature References
Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin:
M.A. Hughes & A.R. Brash; Biochim. Biophys. Acta
1081
, 347 (1991)
Abstract
In vitro activation of mouse skin protein kinase C by fatty acids and their hydroxylated metabolites:
H.H. Lo, et al.; Lipids
29
, 547 (1994)
Abstract
Differential activation of peroxisome proliferator-activated receptors by eicosanoids:
K. Yu, et al.; J. Biol. Chem.
270
, 23975 (1995)
Abstract
;
Full Text
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans:
Y. Guan, et al.; Am. J. Physiol.
273
, F1013 (1997)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
•
PKC Activators
ALX-350-138
Revised 05-Dec-06
Hexaprenylhydroquinone
SYNONYMS
HPH
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antiviral / anti-HIV Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-138-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
36
H
54
O
2
MW:
518.8
CAS NUMBER:
119980-00-6
SOURCE/HOST:
Isolated from
Sarcotragus
sp.
PURITY:
≥97% (HPLC)
APPEARANCE:
Off-white to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by MS,
1
H-NMR.
Product Description
Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.
Product Specific Literature References
Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata:
Y. Venkateswarlu and M. Venkata Rami Reddy; J. Nat. Prod.
57
, 1286 (1994)
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays:
S. De Rosa, et al.; J. Nat. Prod.
57
, 1711 (1994)
Abstract
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases:
S. Loya, et al.; Biochem. J.
324
, 721 (1997)
Abstract
;
Full Text
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A:
I. Erdogan-Orhan, et al.; Nat. Prod. Res.
18
, 1 (2004)
Abstract
General Literature References
Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses:
B. Gil, et al.; Eur. J. Pharmacol.
285
, 281 (1995)
Abstract
Further Categories Containing This Product:
PLA2 Inhibitors
•
Natural Products - DNA Replication Inhibitors
•
HIV / AIDS / Related Products
ALX-202-057
Revised 08-Dec-04
Histone (calf thymus)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-202-057-M010
10 mg
98.00 USD
Product Specification
SOURCE/HOST:
Isolated from calf thymus.
PURITY:
≥98% (SDS-PAGE)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO or aqueous solutions.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Description
Natural mixture of the histones H1, H2A, H2B, H3 and H4.
Further Categories Containing This Product:
Natural Proteins
ALX-260-137
Revised 17-Jan-06
Histone Deacetylase Substrate (Fluorometric)
SYNONYMS
HDAC Substrate (Fluorogenic)
Boc-Lys(Ac)-AMC
MAL
N-(4-Methyl-7-aminocoumarinyl)-N
α
-(t-butoxycarbonyl)-N
ω
-acetyllysineamide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
HDAC Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-137-M001
1 mg
35.00 USD
ALX-260-137-M005
5 mg
105.00 USD
Product Specification
SEQUENCE:
Boc-Lys(Ac)-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
23
H
31
N
3
O
6
MW:
445.5
PURITY:
≥99%
APPEARANCE:
White crystalline solid
SOLUBILITY:
Soluble in DMSO and 100% ethanol (1mg/ml)
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
A fluorogenic substrate for histone deacetylase (HDAC). Ex(max): 330nm; Em(max): 395nm.
Product Specific Literature References
A non-isotopic assay for histone deacetylase activity:
K. Hoffmann, et al.; Nucl. Acids Res.
27
, 2057 (1999)
Abstract
ALX-201-176
Revised 30-Sep-05
Histone γ-H2AX (human) (recombinant)
SYNONYMS
Histone H2AFX (human) (recombinant)
Histone H2A.X (human) (recombinant)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-176-M001
1 mg
290.00 USD
ALX-201-176-M005
5 mg
1'160.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥98% (SDS-PAGE; HPLC)
FORMULATION:
Lyophilized.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-202-029
Revised 08-Dec-04
Histone H1 (calf thymus)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histones / Related Products
Ordering Information
Product Numbers:
Format:
