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ALX-210-163
Revised 14-Nov-05
Polyclonal Antibody to Thyroid Hormone Receptor α-1
SYNONYMS
anti-TRα-1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Thyroid Hormones & Thyroid Hormone Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-163-R100
100 µl
524.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 403-410 (E
403
VFEDQEV
410
) of human TRα-1 (thyroid hormone receptor α-1).
SPECIFICITY:
Recognizes human and chicken TRα-1. Detects a band of ~48kDa by Western blot. Does not cross-react with TRα-2 or TRβ-1.
APPLICATION:
Gel Supershift Assay
Immunocytochemistry
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-165
Revised 21-Dec-06
Polyclonal Antibody to Thyroid Hormone Receptor β-1
SYNONYMS
anti-TRβ-1 PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Thyroid Hormones & Thyroid Hormone Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-165-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 67-86 (I
67
FHLDHDDVNDQSVSSAQTF
86
) of human TRβ-1 (thyroid hormone receptor β-1).
SPECIFICITY:
Recognizes human and rat TRβ-1. Detects a band of ~55kDa by Western blot. Does not cross-react with TRα-1 or TRα-2.
APPLICATION:
Gel Supershift Assay
Immunocytochemistry
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-178
Revised 11-Nov-05
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-178-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Epitope affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 512-530(C
512
CSTEDSKSKEGSQNLQSQ
530
) of C-terminal mouse ERβ (estrogen receptor β
).
SPECIFICITY:
Recognizes human and rat ERβ.
D
etects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION:
Immunohistochemistry (frozen sections (1-2µg/ml), paraffin sections (1-2µg/ml))
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-030
.
Related Products
ALX-155-030
Blocking Peptide for PAb to Estrogen Receptor β (Prod. No.
ALX-210-178
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-180
Revised 21-Dec-06
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-180-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 512-530(C
512
SPAEDSKSK
EGSQNPQSQ
530
) of C-terminal human ERβ (estrogen receptor β
).
SPECIFICITY:
Recognizes human and rat ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION:
Immunohistochemistry (frozen sections (2-5µg/ml), paraffin sections (2-5µg/ml))
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-029
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Differential Regulation of Estrogen Receptor Subtypes alpha and beta in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol
:
F. Barchiesi, et al.; J. Clin. Endocrinol. Metab.
89
, 2373 (2004)
Abstract
;
Full Text
Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast:
R.K. Dubey, et al.; J. Clin. Endocrinol. Metab.
90
, 247 (2005)
Abstract
;
Full Text
Related Products
ALX-155-029
Blocking Peptide for PAb to Estrogen Receptor β (human) (Prod. No.
ALX-210-180
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-190/1
Revised 25-Aug-08
Polyclonal Antibody to PPARα (mouse)
SYNONYMS
anti-Peroxisome Proliferator Activated Receptor α (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-190/1-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
VDTESPICP
LSPLEADD
18
) of mouse PPARα
(peroxisome proliferator activated receptor α). A single aa substitution (I
8
to L
8
) exists between the mouse and human protein.
SPECIFICITY:
Recognizes mouse PPARα. Detects a band of ~52kDa by Western blot. Does not cross-react with PPARδ or PPARγ.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1:1’000)
Functional Application (inhibits PPARα DNA binding)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-029
.
Related Products
ALX-165-029
Blocking Peptide for PAb to PPARα (mouse) (Prod. No.
ALX-210-190/1
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-191/1
Revised 26-May-08
Polyclonal Antibody to PPARδ
SYNONYMS
anti-Peroxisome Proliferator Activated Receptor δ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-191/1-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-14 (M
1
EQPQEETPE
AREE
14
) of mouse PPARδ (peroxisome proliferator activated receptor δ). This sequence is ~86% conserved in human PPARδ.
SPECIFICITY:
Recognizes mouse and rat PPARδ . Detects a band of ~49kDa by Western blot. Does not cross-react with PPARα or PPARγ.
APPLICATION:
Immunocytochemistry (1:100)
Immunohistochemistry (frozen sections (1:200))
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-030
.
Related Products
ALX-165-030
Blocking Peptide for PAb to PPARδ (mouse) (Prod. No.
ALX-210-191/1
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-192
Revised 12-Oct-05
Polyclonal Antibody to PPARγ2 (mouse)
SYNONYMS
anti-Peroxisome Proliferator Activated Receptor γ2 (mouse) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-192-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-16 (M
1
GETLGDSPIDPESDS
16
) of human PPARγ2 (peroxisome proliferator activated receptor γ2).
SPECIFICITY:
Recognizes mouse PPARγ2. Detects a band of ~56kDa by Western blot. Does not cross-react with PPARα or PPARδ.
APPLICATION:
Gel Supershift Assay
Immunohistochemistry (1:500)
Western Blot (1:500)
Functional Application (inhibits PPARγ2 DNA binding)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-031
.
Product Specific Literature References
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
:
R.M. Lavinsky, et al.; PNAS
95
, 2920 (1998)
Abstract
;
Full Text
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages
:
A.A. Von Knethen & B. Brune; FASEB J.
15
, 535 (2001)
Abstract
;
Full Text
Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst
:
A. Von Knethen & B. Brune; J. Immunol.
169
, 2619 (2002)
Abstract
;
Full Text
A human peripheral blood monocyte-derived subset acts as pluripotent stem cells
:
Y. Zhao, et al.; PNAS
100
, 2426 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-201
Revised 22-May-06
Polyclonal Antibody to Estrogen Receptor α
SYNONYMS
anti-ERα PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-201-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-21 (M
1
TMTLHTKASGMALLHQIQGN
21
) of N-terminal human ERα (estrogen receptor α). This sequence is completely conserved in rat and mouse ERα and is highly conserved in sheep, pig, dog, bovine and chicken ERα.
SPECIFICITY:
Recognizes human and rat endogenous ERα . Detects a band of ~64kDa by Western blot. Does not cross-react with ERβ.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections (1-5µg/ml))
Western Blot (1µg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-031
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Differential Regulation of Estrogen Receptor Subtypes alpha and beta in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol:
F. Barchiesi, et al.; J. Clin. Endocrinol. Metab.
89
, 2373 (2004)
Abstract
Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast:
R.K. Dubey, et al.; J. Clin. Endocrinol. Metab.
90
, 247 (2005)
Abstract
;
Full Text
Related Products
ALX-155-031
Blocking Peptide for PAb to Estrogen Receptor α (Prod. No.
ALX-210-201
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-202
Revised 20-Dec-07
Polyclonal Antibody to Estrogen Receptor α
SYNONYMS
anti-ERα PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-202-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Pig
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 21-32 (N
21
ELEPLNRPQLK
32
) of N-terminal human ERα (estrogen receptor α). This sequence is completely conserved in mouse, rat, rabbit, sheep, pig and bovine ERα.
SPECIFICITY:
Recognizes human, rat and pig endogenous ERα. Detects a band of ~64kDa by Western blot. Does not cross-react with ERβ.
APPLICATION:
Immunocytochemistry (0.5µg/ml)
Immunohistochemistry (frozen sections, paraffin sections (1-5µg/ml))
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-032
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-155-032
Blocking Peptide for PAb to Estrogen Receptor α (Prod. No.
ALX-210-202
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-219
Revised 07-Dec-06
Polyclonal Antibody to PARP-1 (197-214)
SYNONYMS
anti-Poly(ADP-ribose) Polymerase-1 (197-214) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PARP-1
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-219-R100
100 µl
240.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 197-214 (K
197
QLPGVKSE
GKRKGDEVD
214
) of human PARP-1 (poly(ADP-ribose) polymerase-1).
SPECIFICITY:
Recognizes human, bovine and chicken PARP-1. Detects bands of ~116kDa (full length PARP-1) and ~29kDa (apoptosis-induced cleavage fragment) by Western blot.
APPLICATION:
ELISA (1:100’000)
Immunocytochemistry (1:50)
Western Blot (1:10’000-1:15’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study:
D. Lamarre, et al.; Biochim. Biophys. Acta
950
, 147 (1988)
Abstract
General Information
During apoptosis PARP-1 is cleaved between Asp
214
and Gly
215
to yield two fragments of 29kDa and 85kDa. This cleavage site is conserved in human, bovine and chicken PARP-1.
Further Categories Containing This Product:
Apoptosis & Necrosis Detection Other Products
•
Polyclonal Antibodies
ALX-210-220
Revised 07-Dec-06
Polyclonal Antibody to PARP-1 (215-228)
SYNONYMS
anti-Poly(ADP-ribose) Polymerase-1 (215-228) PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PARP-1
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-220-R100
100 µl
240.00 USD
