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ALX-380-084
Revised 30-Oct-07
Actinomycin X0δ
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-380-084-C200
200 µg
70.00 USD
Product Specification
FORMULA:
C
62
H
86
N
12
O
17
MW:
1271.5
SOURCE/HOST:
Isolated from
Streptomyces sp.
PURITY:
≥98% (contains traces of ethyl acetate or cyclohexane)
APPEARANCE:
Red crystals.
SOLUBILITY:
Soluble in methanol, acetone or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep cool and dry.
HAZARD:
TOXIC.
IDENTITY:
Determined by
1
H-NMR: Identical to standard reference.
Product Description
Antitumor antibiotic.
Product Specific Literature References
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry:
S. Cho, et al.; Arch. Pharm. Res.
17
, 424 (1994)
Abstract
Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors
•
Transcription Inhibitors / Related Products
ALX-380-085
Revised 30-Oct-07
Actinomycin Z1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-380-085-C200
200 µg
70.00 USD
Product Specification
FORMULA:
C
62
H
84
N
12
O
19
MW:
1301.5
SOURCE/HOST:
Isolated from
Streptomyces sp.
PURITY:
≥95% (contains traces of ethyl acetate or cyclohexane)
SOLUBILITY:
Soluble in methanol, acetone or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep cool and dry.
HAZARD:
TOXIC.
IDENTITY:
Determined by
1
H-NMR: Identical to standard reference.
Product Description
Antitumor antibiotic.
Product Specific Literature References
Identification of actinomycins by high performance liquid chromatography and fast atom bombardment mass spectrometry:
S. Cho, et al.; Arch. Pharm. Res.
17
, 424 (1994)
Abstract
Further Categories Containing This Product:
Transcription Inhibitors / Related Products
ALX-340-038
Revised 08-Sep-08
Leukotriene B4
SYNONYMS
LTB
4
5,12-Dihydroxy-[S-[R*,S*-(E,Z,Z,E)]]-6,8,10,14-eicosatetraenoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes
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ALX-340-038-C025
25 µg
170.00 USD
Product Specification
FORMULA:
C
20
H
32
O
4
MW:
336.5
CAS NUMBER:
71160-24-2
MERCK INDEX:
14:
5455
CONCENTRATION:
0.1mg/ml
PURITY:
≥97%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (1mg/ml). Solvents should be free of oxygen, transition metal ions, and redox active compounds.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light and oxygen.
Product Description
Activator of PPARα. Stimulates a number of leukocyte functions, including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis.
Product Specific Literature References
Leukotriene B4 and inflammatory disease:
R.M. McMillan & S.J. Foster; Agents Actions
24
, 114 (1988)
Abstract
The PPARalpha-leukotriene B4 pathway to inflammation control:
P.R. Devchand, et al.; Nature
384
, 39 (1996)
Abstract
Leukotriene B4:
S.W. Crooks & R.A. Stockley; Int. J. Biochem. Cell Biol.
30
, 173 (1998), (Review)
Abstract
The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells:
M. Heimbürger & J. Palmblad; BBRC
249
, 371 (1998)
Abstract
Ligand selectivity of the peroxisome proliferator-activated receptor alpha:
Q. Lin, et al.; Biochemistry
38
, 185 (1999)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PPAR Agonists
ALX-480-056
Revised 26-Mar-08
Guanosine 5'-O-(3-thiotriphosphate) . tetralithium salt
SYNONYMS
GTP-γ-S . 4Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Guanosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-480-056-M001
1 mg
45.00 USD
ALX-480-056-M005
5 mg
180.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
13
P
3
S . 4Li
MW:
535.2 . 27.8
CAS NUMBER:
94825-44-2
PURITY:
≥
88
%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Analog of guanosine 5'-O-triphosphate (GTP) with resistance to enzymatic hydrolysis. Stimulates inositol trisphosphate formation in membranes.
Product Specific Literature References
G proteins: transducers of receptor-generated signals:
A.G. Gilman; Ann. Rev. Biochem.
56
, 615 (1987)
Abstract
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C:
S. Orellana, et al.; J. Biol. Chem.
262
, 1638 (1987)
Abstract
;
Full Text
A functional role for GTP-binding proteins in synaptic vesicle cycling:
S.D. Hess, et al.; Science
259
, 1169 (1993)
Abstract
ALX-480-057
Revised 16-Dec-04
Guanosine 5'-triphosphate . dilithium salt
SYNONYMS
GTP . 2Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Guanosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
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ALX-480-057-M005
5 mg
16.00 USD
ALX-480-057-M025
25 mg
33.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
14
P
3
. 2Li
MW:
519.2 . 13.9
CAS NUMBER:
85737-04-8 (free acid)
PURITY:
≥97%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Prepared by enzymatic phosphorylation of 5'-GMP. This salt form is much more stable than the sodium salt.
ALX-480-059
Revised 09-Mar-06
Guanosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
cGMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
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ALX-480-059-M025
25 mg
25.00 USD
ALX-480-059-M100
100 mg
95.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
7
P . Na
MW:
344.2 . 23.0
CAS NUMBER:
40732-48-7
MERCK INDEX:
14:
2709
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Intracellular messenger implicated in mediating action of nitric oxide (NO) in many cell types. Target receptors for the second messenger guanosine 3',5'-cyclic monophosphate (cGMP) include protein kinase G (PKG) isozymes, cGMP-dependent ion channels as well as cGMP-responsive phosphodiesterases. In presence of corresponding phosphodiesterases cGMP is metabolized rapidly. Suppresses apoptosis.
Product Specific Literature References
Cyclic GMP metabolism and involvement in biological regulation:
N.D. Goldberg & M.K. Haddox; Ann. Rev. Biochem.
46
, 823 (1977)
Abstract
Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production:
S.Y. Chun, et al.; Endocrinology
136
, 3120 (1995)
Abstract
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
•
Apoptosis Inducers & Inhibitors Other Products
ALX-420-029
Revised 22-Feb-08
GW1929
SYNONYMS
N
-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist
(2S)-((2-Benzoylphenyl)amino-3-[4-[2-(methylpyridin-2-ylamino)ethoxy]phenyl)propionic acid
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Agonists
Ordering Information
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ALX-420-029-M001
1 mg
80.00 USD
ALX-420-029-M005
5 mg
360.00 USD
Product Specification
FORMULA:
C
30
H
29
N
3
O
4
MW:
495.6
PURITY:
≥97%
APPEARANCE:
Off-white to yellow crystalline solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Potent (<10nM) and subtype-selective (>1'000-fold) PPARγ agonist which does not contain a thiazolidinedione moiety. The glucose-lowering effect of GW1929 in rats is 100-fold more potent than that of troglitazone (Prod. No.
ALX-270-355
).
Product Specific Literature References
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents
:
B.R. Henke, et al.; J. Med. Chem.
41
, 5020 (1998)
Abstract
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929
:
W.C. Huang, et al.; Exp. Cell Res.
277
, 192 (2002)
Abstract
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications:
T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab.
90
, 3534 (2005)
Abstract
;
Full Text
ALX-350-289
Revised 05-Apr-08
10Z-Hymenialdisine
SYNONYMS
4-(2-Amino-4-oxo-2-imidazolin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-
c
]azepin-8-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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Product Numbers:
Format:
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ALX-350-289-C500
500 µg
190.00 USD
Product Specification
FORMULA:
C
11
H
10
BrN
5
O
2
MW:
324.1
CAS NUMBER:
82005-12-7
SOURCE/HOST:
Isolated from sponge
Axinella damicornis
(
Stylissa damicornis
).
PURITY:
≥97%
APPEARANCE:
Yellow needles.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Originally isolated from the sponges
Axinella verrucosa
and
Acantella aurantiaca
. Potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC
50
=6nM). Blocks the
in vivo
phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-β (GSK-3β) and CDK5/p35 in Alzheimer’s disease. Inhibitor of DNA damage checkpoint at G2 phase (IC
50
=6µM), cyclin-dependent kinases CDK1/cyclin B (IC
50
=22nM), CDK2/cyclin A (IC
50
=70nM), CDK2/cyclin E (IC
50
=40nM), CDK4/cyclin D1 (IC
50
=600nM), CDK5/p25 (IC
50
=28nM), GSK-3β
(IC
50
=10nM), and
casein kinase 1 (CK1) (IC
50
=35nM). Inhibitor of NF-κB activation and of various pro-inflammatory cytokines such as IL-1, IL-2 (IC
50
=2.4µM), IL-6, IL-8, TNF-α (IC
50
=1.4µM) and nitric oxide (NO) (IC
50
=0.8µM) in a variety of cell lines.
Product Specific Literature References
Isolation and x-ray crystal structure of a novel bromo-compound from two marine sponges
:
G. Cimino, et al.; Tetrahedron Lett.
23
, 767 (1982)
Bioactive alkaloids from the tropical marine sponge Axinella carteri
:
A. Supriyono, et al.; Z. Naturforsch. [C]
50
, 669 (1995)
Abstract
The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-kappaB
:
J.J. Breton & M.C. Chabot-Fletcher; J. Pharmacol. Exp. Ther.
282
, 459 (1997)
Abstract
;
Full Text
Inhibition of NFkappaB-mediated interleukin-1beta-stimulated prostaglandin E2 formation by the marine natural product hymenialdisine
:
A. Roshak, et al.; J. Pharmacol. Exp. Ther.
283
, 955 (1997)
Abstract
;
Full Text
Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine
:
A.M. Badger, et al.; J. Pharmacol. Exp. Ther.
290
, 587 (1999)
Abstract
;
Full Text
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent
:
L. Meijer, et al.; Chem. Biol.
7
, 51 (2000)
Abstract
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine
:
D. Curman, et al.; J. Biol. Chem.
276
, 17914 (2001)
Abstract
;
Full Text
An investigation of cell proliferation and soluble mediators induced by interleukin 1beta in human synovial fibroblasts: comparative response in osteoarthritis and rheumatoid arthritis
:
H. Inoue, et al.; Inflamm. Res.
50
, 65 (2001)
Abstract
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1)
:
D. Tasdemir, et al.; J. Med. Chem.
45
, 529 (2002)
Abstract
Inhibition of cytokine production by hymenialdisine derivatives
:
V. Sharma, et al.; J. Med. Chem.
47
, 3700 (2004)
Abstract
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
MAPK Pathway Inhibitors
•
Natural Products - NF-kB Pathway Inhibitors
•
Natural Products for Cell Cycle Research
•
Natural Products - Nitric Oxide Pathway Modulators
•
NF-kB Pathway Inhibitors
•
DNA Damage Checkpoint Other Products
•
Alkaloids
•
GSK-3 Inhibitors
ALX-270-356
Revised 04-May-06
GW9662
SYNONYMS
2-Chloro-5-nitrobenzanilide
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Antagonists
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-356-M001
1 mg
10.00 USD
ALX-270-356-M005
5 mg
35.00 USD
ALX-270-356-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
13
H
9
N
2
O
3
Cl
MW:
276.7
CAS NUMBER:
22978-25-2
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (Prod. No.
ALX-270-353
).
Product Specific Literature References
IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1
:
A.C. Bendixen, et al.; PNAS
98
, 2443 (2001)
Abstract
;
Full Text
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662
:
L.M. Leesnitzer, et al.; Biochemistry
41
, 6640 (2002)
Abstract
Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells
:
M. Fu, et al.; BBRC
294
, 597 (2002)
Abstract
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications:
T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab.
90
, 3534 (2005)
Abstract
;
Full Text
ALX-300-301
Revised 08-Jul-08
PAz-PC
SYNONYMS
1-Palmitoyl-2-azelaoyl-
sn-
glycero-3-phosphocholine
1-O-Hexadecanoyl-2-O-(9-carboxyoctanoyl)-
sn
-glycero-3-phosphocholine
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PPAR Agonists
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-300-301-M001
1 mg
55.00 USD
ALX-300-301-M005
5 mg
245.00 USD
