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Poly(ADP-ribose) Polymerase [PARP] / Related Products
You are here: Product Lines > DNA Regulation / Transcription > Poly(ADP-ribose) Polymerase [PARP] / Related Products
 
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ALX-270-444 Revised 07-Apr-08 New product
ABT-888
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SYNONYMS 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-444-M001   1 mg 50.00 USD Add To Cart
ALX-270-444-M005   5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C13H16N4O . 2HCl
MW: 244.3 . 73.0
CAS NUMBER: 912445-05-7
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to white crystalline solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents.
Product Specific Literature References
Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models: J.M. Albert, et al.; Clin. Cancer Res. 13, 3033 (2007) Abstract
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models: C.K. Donawho, et al.; Clin. Cancer Res. 13, 2728 (2007) Abstract
 
 
ALX-480-094 Revised 09-Apr-08
ADP-HPD . ammonium salt . dihydrate
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SYNONYMS Adenosine 5'-diphosphate (hydroxymethyl) pyrrolidinediol . NH4 . 2H2O
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-094-C060   60 µg 188.00 USD Add To Cart
Product Specification
FORMULA: C15H23N6O12P2 . NH4 . 2H2O
MW: 541.3 . 18.0 . 36.0
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Hygroscopic.

Product Description
Potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50=120nM) versus ADP-ribose (IC50=120µM). Does not affect the activities of either PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1mM concentration.
Product Specific Literature References
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 389 (1995) Abstract
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol: J.T. Slama, et al.; J. Med. Chem. 38, 4332 (1995) Abstract
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage: S. Vispe, et al.; PNAS 97, 9886 (2000) Abstract; Full Text
Further Categories Containing This Product:
PARG / Related Products • DNA Repair Other Products
 
 
ALX-270-285 Revised 11-Aug-06
5-AIQ . hydrochloride
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SYNONYMS 5-Aminoisoquinolinone . HCl
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Repair Other Products
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ALX-270-285-M001   1 mg 50.00 USD Add To Cart
ALX-270-285-M005   5 mg 175.00 USD Add To Cart
Product Specification
FORMULA: C9H8N2O . HCl
MW: 160.2 . 36.5
PURITY: ≥97%
APPEARANCE: Beige to brown powder.
SOLUBILITY: Soluble in water (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: IRRITANT.

Product Description
Water-soluble, potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on the organ injury and dysfunction caused by haemorrhagic shock: M.C. McDonald, et al.; Br. J. Pharmacol. 130, 843 (2000) Abstract
Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury: S. Cuzzocrea, et al.; Biochem. Pharmacol. 63, 293 (2002) Abstract
Further Categories Containing This Product:
PARP Inhibitors
 
 
ALX-270-044 Revised 25-Sep-06
3-Aminobenzamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-044-G001   1 g 50.00 USD Add To Cart
ALX-270-044-G005   5 g 190.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O
MW: 136.2
CAS NUMBER: 3544-24-9
RTECS: CU8992000
PURITY: ≥97%
APPEARANCE: White to tan powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. Apoptosis inhibitor.
Product Specific Literature References
Signal transduction in Coprinus congregatus: evidence for the involvement of G proteins in blue light photomorphogenesis: K.R. Kozak and I.A. Ross; BBRC 179, 1225 (1991) Abstract
Cell death protection by 3-aminobenzamide and other poly(ADP- ribose)polymerase inhibitors: different effects on human natural killer and lymphokine activated killer cell activities: D. Monti, et al.; BBRC 199, 525 (1994) Abstract
Cell death protection by 3-aminobenzamide: impairment of cytoskeleton function in human NK cell-mediated killing: W. Malorni, et al.; BBRC 199, 1250 (1994) Abstract
3-Aminobenzamide protects cells from UV-B-induced apoptosis by acting on cytoskeleton and substrate adhesion: W. Malorni, et al.; BBRC 207, 715 (1995) Abstract
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells: B. Heller, et al.; J. Biol. Chem. 270, 11176 (1995) Abstract
Inhibitors of poly(ADP-ribose) polymerase block nitric oxide-induced apoptosis but not differentiation in human leukemia HL-60 cells: M.L. Kuo, et al.; BBRC 219, 502 (1996) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-270-250 Revised 18-Jan-06
4-Amino-1,8-naphthalimide
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SYNONYMS 4-ANI
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-250-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C12H8N2O2
MW: 212.2
CAS NUMBER: 1742-95-6
RTECS: DE4081000
PURITY: ≥95%
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for 3 months when stored at –20°C.
HAZARD: IRRITANT.

Product Description
Potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) (IC50=0.18µM). About 1000-fold more potent than 3-aminobenzamide (Prod. No. ALX-270-044).
Product Specific Literature References
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992) Abstract; Full Text
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion: J. Radons, et al.; BBRC 199, 1270 (1994) Abstract
Combination effects of poly(ADP-ribose) polymerase inhibitors and DNA-damaging agents in ovarian tumor cell lines--with special reference to cisplatin: F. Bernges & W.J. Zeller; J. Cancer Res. Clin. Oncol. 122, 665 (1996) Abstract
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle: C. Thiemermann, et al.; PNAS 94, 679 (1997) Abstract; Full Text
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: a comparison with radical scavengers: J. Bowes & C. Thiemermann; Br. J. Pharmacol. 124, 1254 (1998) Abstract
4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer: A. Schlicker, et al.; Int. J. Radiat. Biol. 75, 91 (1999) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-201-290 Revised 06-Aug-08 New product
ARH1 (human) (recombinant) (His)
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SYNONYMS ADP-ribosylarginine Hydrolase (human) (recombinant) (His)
ADPRH (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
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ALX-201-290-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.2.19
SOURCE/HOST: Produced in E. coli. Human ARH1 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of ADP-ribosylagmatine and proteins ADP-ribosylated on arginine residues
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation: C. Mueller-Dieckmann, et al.; PNAS 103, 15026 (2006) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P54922: ADPRH (human)
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-292 Revised 06-Aug-08 New product
ARH3 (human) (recombinant) (His)
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SYNONYMS ADP-ribosylhydrolase 3 (human) (recombinant) (His)
ADPRHL2 (human) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-292-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.1.143
SOURCE/HOST: Produced in E. coli. Human ARH3 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of poly-ADP-ribosylated proteins
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation: C. Mueller-Dieckmann, et al.; PNAS 103, 15026 (2006) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9NX46: ADPRHL2 (human)
General Literature References
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix: M. Niere, et al.; Mol. Cell. Biol. 28, 814 (2008) Abstract; Full Text
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-291 Revised 06-Aug-08 New product
ARH1 (mouse) (recombinant) (His)
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SYNONYMS ADP-ribosylarginine Hydrolase (mouse) (recombinant) (His)
Adprh (mouse) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-291-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.2.19
SOURCE/HOST: Produced in E. coli. Mouse ARH1 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of ADP-ribosylagamatine and proteins ADP-ribosylated on arginine residues.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P54923: Adprh (mouse)
General Literature References
Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases: P. Konczalik & J. Moss; J. Biol. Chem. 274, 16736 (1999) Abstract; Full Text
Functional aspects of protein mono-ADP-ribosylation: D. Corda & M. Di Girolamo; EMBO J. 22, 1953 (2003) Abstract; Full Text
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation: C. Mueller-Dieckmann, et al.; PNAS 103, 15026 (2006) Abstract; Full Text
Enhanced sensitivity to cholera toxin in ADP-ribosylarginine hydrolase-deficient mice: J. Kato, et al.; Mol. Cell. Biol. 27, 5534 (2007) Abstract; Full Text
Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases: F. Koch-Nolte, et al.; Front. Biosc. 13, 6716 (2008) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-293 Revised 06-Aug-08 New product
ARH3 (mouse) (recombinant) (His)
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SYNONYMS ADP-ribosylhydrolase 3 (mouse) (recombinant) (His)
Adprhl2 (mouse) (recombinant) (His)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Mono(ADP-ribosyl)transferases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-293-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 3.2.1.143
SOURCE/HOST: Produced in E. coli. Mouse ARH3 is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥98%
PURITY DETAIL: Affinity purified
FORMULATION: Liquid. In PBS containing 50% glycerol.
APPLICATION: Functional Application (1:10-1:100): Hydrolysation of poly-ADP-ribo