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ALX-350-104
Revised 10-May-07
Aaptamine
SYNONYMS
8,9-Dimethoxy-1
H
-benzo[
de
][1,6]naphtyridine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
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ALX-350-104-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
2
MW:
228.3
CAS NUMBER:
85547-22-4
SOURCE/HOST:
Isolated from the sponge
Aaptos aaptos
.
PURITY:
≥97%
APPEARANCE:
Oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.
Product Specific Literature References
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle
:
Y. Ohizumi, et al.; J. Pharm. Pharmacol.
36
, 785 (1984)
Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine:
G.R. Pettit, et al.; J. Org. Chem.
69
, 2251 (2004)
Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner:
S. Aoki, et al.; BBRC
342
, 101 (2006)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
•
Adrenergics & Adrenergic Receptors / Related Products
•
Natural Products - Antitumor Reagents
•
Marine Natural Products
•
Alkaloids
ALX-550-208
Revised 17-Dec-04
N-Acetyl-5-hydroxytryptamine
SYNONYMS
N-Acetylserotonin
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Melatonin Receptors / Related Products
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ALX-550-208-M010
10 mg
10.00 USD
ALX-550-208-M050
50 mg
25.00 USD
ALX-550-208-M500
500 mg
125.00 USD
Product Specification
FORMULA:
C
12
H
14
N
2
O
2
MW:
218.3
CAS NUMBER:
1210-83-9; 17994-17-1
PURITY:
≥99%
APPEARANCE:
Off-white powder.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Metabolite of serotonin (Prod. No.
ALX-550-328
). Precursor of melatonin (Prod. No.
ALX-550-071
). Inhibitor of hydroxyindole-O-methyltransferase.
Product Specific Literature References
The metabolism of serotonin (5-hydroxytryptamine)
:
W.M. McIsaac and I.H. Page; J. Biol. Chem.
234
, 858 (1959)
Full Text
Hydroxyindole-O-methyltransferase. I. Substrate binding:
B.T. Ho, et al.; J. Pharm. Sci.
58
, 130 (1969)
Abstract
Hydroxyindole-O-methyltransferase. II. Inhibitory activities of some N- acyltryptamines:
B.T. Ho, et al.; J. Pharm. Sci.
57
, 1998 (1968)
Abstract
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors / Related Products
ALX-550-200
Revised 09-Aug-02
N-Acetyltryptamine
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Melatonin Receptors / Related Products
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ALX-550-200-M005
5 mg
50.00 USD
ALX-550-200-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
12
H
14
N
2
O
MW:
202.3
CAS NUMBER:
1016-47-3
PURITY:
≥97%
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Partial agonist for melatonin receptors.
Product Specific Literature References
Characterization of a retinal melatonin receptor:
M.L. Dubocovich; J. Pharmacol. Exp. Ther.
234
, 395 (1985)
Abstract
Luzindole (N-0774): a novel melatonin receptor antagonist:
M.L. Dubocovich; J. Pharmacol. Exp. Ther.
246
, 902 (1988)
Abstract
ALX-350-326
Revised 29-May-07
Agelongine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-350-326-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
13
H
11
BrN
2
O
4
MW:
339.1
CAS NUMBER:
163564-84-9
SOURCE/HOST:
Isolated from the sponge
Agelas longissima
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Alkaloid exhibiting antagonistic activity on serotonin receptors.
Product Specific Literature References
A novel bromopyrrole alkaloid from the sponge agelas longissima with antiserotonergic activity:
F. Cafieri, et al.; Bioorg. Med. Chem. Lett.
5
, 799 (1995)
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent:
L. Meijer, et al.; Chem. Biol.
7
, 51 (2000)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Marine Natural Products
•
Serotonergics & Serotonin Receptors / Related Products
ALX-550-320
Revised 07-Dec-04
Benserazide . hydrochloride
SYNONYMS
DL-Serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-320-G001
1 g
35.00 USD
ALX-550-320-G005
5 g
135.00 USD
Product Specification
FORMULA:
C
10
H
15
N
3
O
5
. HCl
MW:
257.3 . 36.5
CAS NUMBER:
14919-77-8
MERCK INDEX:
14:
1050
PURITY:
≥98%
APPEARANCE:
White to tan solid.
SOLUBILITY:
Soluble in water. Almost insoluble in 100% ethanol; insoluble in acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Peripheral inhibitor of dopa decarboxylase
in vitro
and
in vivo
.
Product Specific Literature References
Levodopa and decarboxylase inhibitors: a review of their clinical pharmacology and use in the treatment of parkinsonism:
R.M. Pinder, et al.; Drugs
11
, 329 (1976)
Abstract
Single-dose study of slow release preparation of levodopa and benserazide (Madopar HBS) in Parkinson's disease:
M.-H. Marion, et al.; Adv. Neurol.
45
, 493 (1987)
Abstract
ALX-550-204
Revised 13-Dec-04
N-[1-(2-Benzo[b]thien-2-yl)cyclohexyl)]piperidine . maleate
SYNONYMS
BTCP . maleate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-204-M005
5 mg
75.00 USD
ALX-550-204-M025
25 mg
300.00 USD
Product Specification
FORMULA:
C
19
H
25
NS . C
4
H
4
O
4
MW:
299.5 . 116.1
CAS NUMBER:
112726-66-6
PURITY:
≥98%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potent dopamine re-uptake inhibitor.
Product Specific Literature References
[3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP): a new phencyclidine analog selective for the dopamine uptake complex:
J. Vignon, et al.; Eur. J. Pharmacol.
148
, 427 (1988)
Abstract
The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801:
W. Koek, et al.; J. Pharmacol. Exp. Ther.
250
, 1019 (1989)
Abstract
Differential interaction of phencyclidine-like drugs with the dopamine uptake complex in vivo:
T. Maurice, et al.; J. Neurochem.
56
, 553 (1991)
Abstract
Inhibition of locus coeruleus neurons by the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine: evidence for potent indirect adrenoceptor agonist properties:
K. Chergui, et al.; Eur. J. Pharmacol.
219
, 169 (1992)
Abstract
Synthesis and biological evaluation of 1-[1-(2- benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites:
X.S. He, et al.; J. Med. Chem.
36
, 1188 (1993)
Abstract
ALX-550-159
Revised 16-Dec-04
4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine . oxalate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-550-159-M005
5 mg
60.00 USD
Product Specification
FORMULA:
C
20
H
25
N
5
O . C
2
H
2
O
4
MW:
351.5 . 90.0
PURITY:
≥96%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potent pre- and postsynaptic 5-HT
1A
receptor antagonist.
Product Specific Literature References
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2- methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs:
J.L. Mokrosz, et al.; J. Med. Chem.
37
, 2754 (1994)
Abstract
ALX-550-143
Revised 19-Aug-02
Benztropine . mesylate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Acetylcholine Receptors (Muscarinic) / Related Products
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ALX-550-143-G001
1 g
20.00 USD
Product Specification
FORMULA:
C
21
H
25
NO . CH
3
SO
3
H
MW:
307.4 . 96.1
CAS NUMBER:
132-17-2
MERCK INDEX:
14:
1121
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
Muscarinic acetylcholine receptor antagonist. Inhibits the dopamine transporter.
Further Categories Containing This Product:
Dopaminergics & Dopamine Receptors / Related Products
ALX-550-375
Revised 28-Jan-05
BRL 15572 . hydrochloride
SYNONYMS
3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol . HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-550-375-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
25
H
27
ClN
2
O . HCl
MW:
406.9 . 36.5
CAS NUMBER:
193611-72-2
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Selective human 5-HT
1D
antagonist.
Product Specific Literature References
Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig:
J.J. Hagan, et al.; Eur. J. Pharmacol.
331
, 169 (1997)
Abstract
SB-216641 and BRL-15572-compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors:
G.W. Price, et al.; Naunyn Schmiedebergs Arch. Pharmacol.
356
, 312 (1997)
Abstract
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors:
E. Schlicker, et al.; Naunyn Schmiedebergs Arch. Pharmacol.
356
, 321 (1997)
Abstract
5-HT1-like receptors: a time to bid goodbye:
P.R. Saxena, et al.; TIPS
19
, 311 (1998), (Review)
Abstract
The canine external carotid vasoconstrictor 5-HT1 receptor: blockade by 5-HT1B (SB224289), but not by 5-HT1D (BRL15572) receptor antagonists:
P. De Vries, et al.; Eur. J. Pharmacol.
362
, 69 (1998)
Abstract
5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression:
R. Verheggen, et al.; Br. J. Pharmacol.
124
, 1345 (1998)
Abstract
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions:
M. Marcoli, et al.; Br. J. Pharmacol.
126
, 607 (1999)
Abstract
ALX-550-161
Revised 14-Dec-04
N-(4-Bromobenzyl)-5-methoxytryptamine . oxalate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-550-161-M001
1 mg
20.00 USD
ALX-550-161-M005
5 mg
60.00 USD
Product Specification
FORMULA:
C
18
H
19
N
2
OBr . C
2
H
2
O
4
MW:
359.3 . 90.0
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Very potent and selective ligand for 5-HT
2A
receptors.
Product Specific Literature References
Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines:
R.A. Glennon, et al.; J. Med. Chem.
37
, 1929 (1994)
Abstract
ALX-550-041
Revised 10-Sep-07
(+)-Bromocriptine . methanesulfonate
SYNONYMS
2-Bromo-α-ergocryptine . methanesulfonate
(+)-2-Bromo-12'-hydroxy-2'-(1-methyletyhl)-5'-(2-methylpropyl)-ergotaman-3',6'-18-trionemethanesulfonate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-041-M010
10 mg
25.00 USD
ALX-550-041-M050
50 mg
80.00 USD
Product Specification
FORMULA:
C
32
H
40
BrN
5
O
5
. CH
3
SO
3
H
MW:
654.6 . 96.1
CAS NUMBER:
22260-51-1
MERCK INDEX:
14:
1416
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol; slightly soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Agonist at D
2
and D
3
dopamine receptors.
Product Specific Literature References
Bromocriptine produces decreases in cocaine self-administration in the rat:
C.B. Hubner & G.F. Koob; Neuropsychopharmacology
3
, 101 (1990)
Abstract
<
