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ALX-270-221 Revised 23-Jul-07
DPQ
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SYNONYMS 3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-221-M001   1 mg 52.00 USD Add To Cart
ALX-270-221-M005   5 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C18H26N2O2
MW: 302.4
CAS NUMBER: 129075-73-6
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to light brown solid.
SOLUBILITY: Soluble in DMSO; slightly soluble in 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 1 month when stored at -20°C.
HAZARD: HARMFUL.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Very potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor.
Product Specific Literature References
Dihydroisoquinolines: the design and synthesis of a new series of potent inhibitors of poly(ADP-ribose) polymerase: M.J. Suto, et al.; Anticancer Drug Des. 6, 107 (1991) Abstract
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia: M.J.L. Eliasson, et al.; Nat. Med. 3, 1089 (1997) Abstract
Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats: H. Takahashi, et al.; J. Cereb. Blood Flow Metab. 17, 1137 (1997) Abstract
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion: C. Szabo & V.L. Dawson; TIPS 19, 287 (1998), (Review) Abstract
Post-treatment with an inhibitor of poly(ADP)-ribose polymerase attenuates cerebral damage in focal ischemia: K. Takahashi, et al.; Brain Res. 829, 46 (1999) Abstract; Full Text
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia: F. Moroni, et al.; Cell Death Differ. 8, 921 (2001) Abstract
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors: L. Giovannelli, et al.; J. Cereb. Blood Flow Metab. 22, 697 (2002) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
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