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ALX-522-040 Revised 24-Mar-05
DR3 (human):Fc (human) (recombinant)
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SYNONYMS Apo-3 (human):Fc (human) (recombinant)
LARD (human):Fc (human) (recombinant)
TRAMP (human):Fc (human) (recombinant)
TR3 (human):Fc (human) (recombinant)
WSL-1 (human):Fc (human) (recombinant)
TNFRSF 12 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY TWEAK & FN14 / DR3 / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-040-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~55kDa (under reducing conditions).
SOURCE/HOST: Produced in HEK 293 cells. The cysteine-rich region of human DR3 (aa 25-199) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds human TL1A.
APPLICATION: Can be used together with anti-human IgG1 PAb to detect TL1A.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C. After reconstitution, it is recommended to make appropriate aliquots and to store them at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
The DR3 receptor (WSL-1, Apo-3, LARD, TRAMP, TR3) is a member of the tumor necrosis factor receptor (TNF-R) family. DR3 is a type I transmembrane receptor. It is 339 aa long and contains 4 extracellular cysteine-rich motifs in its extracellular domain, while its cytoplasmic region contains a death domain. DR3 is abundantly expressed on thymocytes and T and B lymphocytes. Overexpression of DR3 mediates activation of nuclear factor NF-κB and induces apoptosis. Besides the induction of apoptosis, DR3 has been reported to regulate negative selection during thymocyte development.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q93038: DR3 (human) (precursor)
AfCS Signalling Gateway link A000786: DR3 (mouse)
MANUFACTURER

Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
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