ALEXIS Biochemicals: DTT

ALX-280-001

Revised 25-Jul-08

DTT
SYNONYMS	1,4-Dithio-DL-threitol DL-Dithiothreitol Cleland's Reagent
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Signal Transduction Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-280-001-G005		5 g	70.00 USD
ALX-280-001-G010		10 g	120.00 USD
ALX-280-001-G025		25 g	220.00 USD
ALX-280-001-G050		50 g	350.00 USD

Product Specification

FORMULA:	C₄H₁₀O₂S₂
MW:	154.2
CAS NUMBER:	3483-12-3
MERCK INDEX:	14: 3376
RTECS:	EK1610000
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water, 100% ethanol, acetone or ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	HARMFUL.

Product Description

Cell permeable protective agent for SH groups, maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively.

Product Specific Literature References

Dithiothreitol, A New Protective Reagent For SH Groups: W.W. Cleland; Biochemistry 3, 480 (1964)
Enzyme activity and sulfhydryl status in rat renal cortex following mercuric chloride and dithiothreitol administration: D.R. Klonne & D.R. Johnson; Toxicol. Lett. 42, 199 (1988) Abstract
Molecular mechanism for prevention of N-acetyl-p-benzoquinoneimine cytotoxicity by the permeable thiol drugs diethyldithiocarbamate and dithiothreitol: V.V.M. Lauriault & P.J. O'Brien; Mol. Pharmacol. 40, 125 (1991) Abstract
Cleland's reagents block lethal and hypnotic effects of pentobarbital: L. Gailis; Eur. J. Pharmacol. 292, 39 (1994) Abstract

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