ALEXIS Biochemicals: Dantrolene . sodium salt

ALX-550-072

Revised 28-Jan-05

Dantrolene . sodium salt
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Ca2+ Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-072-M010		10 mg	14.00 USD
ALX-550-072-M050		50 mg	32.00 USD

Product Specification

FORMULA:	C₁₄H₉N₄O₅Na
MW:	336.2
CAS NUMBER:	14663-23-1
MERCK INDEX:	14: 2816
PURITY:	≥99%
APPEARANCE:	Orange solid.
SOLUBILITY:	Soluble in DMSO; insoluble in dilute aqueous base or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Inhibitor of Ca²⁺release from intracellular stores, probably by binding to the ryanodine receptor. Intracellularly acting muscle relaxant.

Product Specific Literature References

1-[(5-arylfurfurylidene)amino]hydantoins. A new class of muscle relaxants: Snyder, et al.; J. Med. Chem. 10, 807 (1967) Abstract
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity: A. Ward, et al.; Drugs 32, 130 (1986) Abstract
Dantrolene sodium diminishes exercise-induced muscle damage in the rat: G.J. Amelink, et al.; Eur. J. Pharmacol. 179, 187 (1990) Abstract
Inhibitory action of dantrolene on Ca-induced Ca2+ release from sarcoplasmic reticulum in guinea pig skeletal muscle: T. Ohta, et al.; Eur. J. Pharmacol. 178, 11 (1990) Abstract
Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2amino3(3hydroxy5methylisoxazol4yl)propionate and kainate in cultured cerebral cortical neurons: A. Frandsen & A. Schousboe; PNAS 89, 2590 (1992) Abstract
Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?: S.K. Song, et al.; PNAS 90, 3933 (1993) Abstract
Possible mechanism of dantrolene stabilization of cultured neuroblastoma cell plasma membranes: T. Hayashi, et al.; J. Neurochem. 63, 1849 (1994) Abstract
NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release: I. Mody & J.F. McDonald; TIPS 16, 356 (1995), (Review) Abstract

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.