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ALX-630-115 Revised 22-May-08 New product
Deoxynivalenol
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SYNONYMS DON
3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Vomitoxin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-115-M001   1 mg 50.00 USD Add To Cart
ALX-630-115-M005   5 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C15H20O6
MW: 296.3
CAS NUMBER: 51481-10-8
RTECS: YD0167000
SOURCE/HOST: Isolated from Trichoderma viride.
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Mycotoxin found in cereals. Binds to the ribosome and inhibits protein synthesis.
Product Specific Literature References
Simultaneous detection of several Fusarium mycotoxins in cereals, grains, and foodstuffs: H. Kamimura, et al.; J. Assoc. Off. Anal. Chem. 64, 1067 (1981) Abstract
Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice: M.E. Gouze, et al.; Cell. Mol. Biol. (Noisy-le-grand) 51, OL809 (2005) Abstract
The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for Fusarium head blight resistance in wheat: M. Lemmens, et al.; Mol. Plant Microbe Interact. 18, 1318 (2005) Abstract
Detection of deoxynivalenol in foods and indoor air using an array biosensor: M.M. Ngundi, et al.; Environ. Sci. Technol. 40, 2352 (2006) Abstract
Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants: J. Pestka & H.R. Zhou; Toxicol. Sci. 92, 445 (2006) Abstract; Full Text
Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum: N. Ponts, et al.; FEMS Microbiol. Lett. 258, 102 (2006) Abstract
Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes: T. Goyarts, et al.; Toxicol. In Vitro 20, 858 (2006) Abstract
Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations: T. Sergent, et al.; Toxicol. Lett. 164, 167 (2006) Abstract
Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages: Q. Jia, et al.; J. Nutr. 136, 366 (2006) Abstract; Full Text
Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens: W.A. Awad, et al.; J. Anim. Physiol. Anim. Nutr. (Berl) 90, 32 (2006) Abstract
The effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan adsorbent on lactation, serum chemistry, and reproductive performance after weaning of first-parity lactating sows: G. Diaz-Llano & T.K. Smith; J. Anim. Sci. 85, 1412 (2007) Abstract
Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture: M. Königs, et al.; Toxicology 240, 48 (2007) Abstract
Some major mycotoxins and their mycotoxicoses--an overview: J.L. Richard; Int. J. Food Microbiol. 119, 3 (2007), (Review) Abstract
Ribotoxic mycotoxin deoxynivalenol induces G(2)/M cell cycle arrest via p21(Cip/WAF1) mRNA stabilization in human epithelial cells: H. Yang, et al.; Toxicology 243, 145 (2008) Abstract
Further Categories Containing This Product:
Translation Inhibitors
 
 

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