ALEXIS Biochemicals: JS-2190

ALX-270-307

Revised 08-Nov-06

JS-2190
SYNONYMS	Boc-Glu(OBzl)-N,N’-dicyclohexylurea
PRODUCT LINE	Cancer
PRODUCT CATEGORY	MDR Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-307-M005		5 mg	170.00 USD

Product Specification

FORMULA:	C₃₀H₄₅N₃O₆
MW:	543.7
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in chloroform (>10%); also soluble in 100% ethanol or ethanol:water 8:1 (mild heating up to 40°C).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

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Product Description

Inhibitor of P-glycoprotein (Pgp) and MRP1. Results obtained with the calcein assay protocol [1] indicate that JS-2190 is efficiently taken up by living cells.

General Literature References

[1] Calcein accumulation as a fluorometric functional assay of the multidrug transporter: Z. Hollo, et al.; Biochim. Biophys. Acta 1191, 384 (1994) Abstract

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