ALEXIS Biochemicals: Becatecarin

ALX-380-119

Revised 21-May-08

Becatecarin
SYNONYMS	6-N-[2-(Diethylamino)ethyl]rebeccamycin NSC 655649 BMY-27557-14 BMS-181176 XL 119
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-119-C250		250 µg	155.00 USD
ALX-380-119-M001		1 mg	465.00 USD

Product Specification

FORMULA:	C₃₃H₃₄Cl₂N₄O₇
MW:	669.6
CAS NUMBER:	119673-08-4
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in water (pH-dependent) or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Semisynthetic water-soluble derivative of rebeccamycin (ALX-380-079). Antitumor antibiotic. Topoisomerase II inhibitor. DNA intercalating agent.

Product Specific Literature References

Water soluble derivatives of rebeccamycin: T. Kaneko, et al.; J. Antibiot. 43, 125 (1990) Abstract
Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles: B.H. Long, et al.; Curr. Med. Chem. Anticancer Agents 2, 255 (2002) Abstract
Becatecarin (Helsinn Healthcare): G.W. Rewcastle; IDrugs 8, 838 (2005) Abstract
Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors: A.D. Ricart, et al.; Clin. Cancer Res. 11, 8728 (2005) Abstract; Full Text

Related Products

ALX-380-079

Rebeccamycin

Further Categories Containing This Product:

Antitumor Agents (DNA Interaction & Gene Regulation) • DNA Intercalators & Crosslinkers • Antibiotics - Topoisomerase Inhibitors

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