ALEXIS Biochemicals: BCMA (mouse):Fc (human) (recombinant)

ALX-522-079

Revised 26-Aug-08

BCMA (mouse):Fc (human) (recombinant)
SYNONYMS	B Cell Maturation Protein (mouse):Fc (human) (recombinant) TNFRSF 17 (mouse):Fc (human) (recombinant) CD269 (mouse):Fc (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	BCMA

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-079-C050		50 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
MW:	~35kDa (SDS-PAGE).
SOURCE/HOST:	Produced in HEK 293 cells. The extracellular domain of mouse BCMA (aa 1-46) is fused at the C-terminus to a linker peptide (2 aa) and the Fc portion of human IgG1.
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY:	Binds mouse and human BAFF and human APRIL.
BIOLOGICAL ACTIVITY:	Blocks the binding of mouse BAFF and human APRIL to their receptors BCMA and TACI, inhibiting BAFF and APRIL-mediated splenocyte survival.
APPLICATION:	Flow Cytometry: Detection of membrane-bound mouse BAFF and human APRIL in combination with fluorescently labelled Ab to human IgG1.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

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Product Specific Literature References

Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen: P. Schneider, et al.; J. Exp. Med. 194, 1691 (2001) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link O88472: BCMA (mouse) AfCS Signalling Gateway link A000374: BCMA (mouse)
MANUFACTURER	Manufactured by Apotech Corporation.