ALEXIS Biochemicals: Monoclonal Antibody to SEL1L (MSel1)

ALX-804-579

Revised 18-Jun-08

Monoclonal Antibody to SEL1L (MSel1)
SYNONYMS	anti-Suppressor of lin-12-like Protein MAb (MSel1)
PRODUCT LINE	Stress & Heat Shock Proteins
PRODUCT CATEGORY	Endoplasmatic Reticulum Stress

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-579-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	MSel1
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human SEL1L (suppressor of lin-12-like protein).
SPECIFICITY:	Recognizes human and mouse SEL1L.
APPLICATION:	Immunohistochemistry (frozen sections; paraffin sections) Immunoprecipitation Western Blot (10µg/ml) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Do not freeze.

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Product Specific Literature References

Production of a monoclonal antibody directed against the recombinant SEL1L protein: R. Orlandi, et al.; J. Biol. Markers 17, 104 (2002) Abstract
SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro: R. Orlandi, et al.; Cancer Res. 62, 567 (2002) Abstract; Full Text

General Information

SEL1L (suppressor of lin-12-like protein) is the human ortholog of the C. elegans sel-1 gene, a negative regulator of the lin-12/Notch family of proteins. Human SEL1L is a component of endoplasmic reticulum-associated degradation (ERAD), involved in ubiquitin-dependent degradation of misfolded ER proteins. In addition, SEL1L plays a role in cancer progression. Several studies provided significant evidence that increased SEL1L expression is linked to a decrease in tumor aggressiveness.

General Literature References

Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1: Y. Harada, et al.; J. Hum. Genet. 44, 330 (1999) Abstract
SEL1L a multifaceted protein playing a role in tumor progression: I. Biunno, et al.; J. Cell Physiol. 208, 23 (2006) Abstract
A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes: M. Kaneko, et al.; FEBS Lett. 581, 5355 (2007) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies • Tumor Suppressors / Related Products

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