© 2008 Alexis Corporation
ALX-164-005 Revised 04-Jul-08
Obestatin (mouse, rat)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-164-005-M001   1 mg 130.00 USD Add To Cart
ALX-164-005-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
FORMULA: C114H174N34O31
MW: 2516.8
PEPTIDE CONTENT: ≥80%
PURITY: ≥97% (HPLC)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.
Product Specific Literature References
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake: J.V. Zhang, et al.; Science 310, 996 (2005) Abstract
Biomedicine. Separation of conjoined hormones yields appetite rivals: R. Nogueiras & M. Tschop; Science 310, 985 (2005), (Comment) Abstract
 
 
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