ALEXIS Biochemicals: Monoclonal Antibody to NS5B (HCV) (5B-12B7)

ALX-803-061

Revised 26-Apr-07

Monoclonal Antibody to NS5B (HCV) (5B-12B7)
SYNONYMS	anti-Nonstructural Protein 5B (HCV) MAb (5B-12B7)
PRODUCT LINE	Viral Signalling
PRODUCT CATEGORY	Hepatitis Viruses / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-061-R100		100 µl	360.00 USD

Product Specification

CLONE:	5B-12B7
ISOTYPE:	Mouse IgG2a
PURITY:	Liquid. Ascites fluid diluted in PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
SPECIFICITY:	Recognizes HCV NS5B (epitope mapped to NS5B aa 139-392).
APPLICATION:	Immunocytochemistry (1:100) Immunoprecipitation Functional Application: Blocks the RNA-dependent RNA polymerase activity in vitro. Note: Not suitable for Western blot. Use MAb to NS5B (HCV) (5B-3B1) (Prod. No. ALX-803-060).
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase: J. Schmidt-Mende, et al.; J. Biol. Chem. 276, 44052 (2001) Abstract; Full Text
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase: D. Moradpour, et al.; J. Biol. Chem. 277, 593 (2002) Abstract; Full Text
Protein-protein interactions between hepatitis C virus nonstructural proteins: Dimitrova, et al.; J. Virol. 77, 5401 (2003) Abstract; Full Text
Interference of hepatitis C virus RNA replication by short interfering RNAs: Kapadia, et al.; PNAS 100, 2014 (2003) Abstract; Full Text

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Unravelling hepatitis C virus replication from genome to function: B.D. Lindenbach and C.M. Rice; Nature 436, 933 (2005) Abstract