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ALX-480-091 Revised 28-Nov-07
8-Hydroxyguanine
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SYNONYMS 8-Oxoguanine
7,8-Dihydro-8-oxoguanine
8-oxoG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-091-M010   10 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C5H5N5O2
MW: 167.1
CAS NUMBER: 5614-64-2
PURITY: ≥90% (contains <10% acetic acid)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in conc. sodium hydroxide. May be further diluted and neutralized with water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer: P. Jaruga, et al.; FEBS Lett. 341, 59 (1994) Abstract
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection: M.K. Shigenaga, et al.; Meth. Enzymol. 234, 16 (1994) Abstract
DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells: J.P. Spencer, et al.; FEBS Lett. 374, 233 (1995) Abstract
DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions: T.H. Zastawny, et al.; Free Radic. Biol. Med. 18, 1013 (1995) Abstract
Oxidative denitrification of the antitumour drug hydroxyguanidine: S.A. Everett, et al.; Free Radic. Biol. Med. 24, 1 (1998) Abstract
8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage: H.J. Helbock, et al.; Meth. Enzymol. 300, 156 (1999) Abstract
Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1: J.W. Hyun, et al.; Oncogene 19, 4476 (2000) Abstract
Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme: N.Y. Tretyakova, et al.; Chem. Res. Toxicol. 13, 658 (2000) Abstract
Further Categories Containing This Product:
Oxidative Stress Markers & Reagents/Related Products • DNA Repair Other Products
 
 
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