ALEXIS Biochemicals: LTα3, Soluble (human) (recombinant)

ALX-522-034

Revised 27-Mar-06

LTα3, Soluble (human) (recombinant)
SYNONYMS	TNF-β, Soluble (human) (recombinant) TNFSF 1, Soluble (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	TNF-alpha & TNF Receptors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-034-C010		10 µg	200.00 USD
ALX-522-034-3010	SuperPack	3x10 µg	410.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
MW:	~25kDa (SDS-PAGE).
SOURCE/HOST:	Produced in E. coli. The extracellular domain of human LTα3 (aa 43-205) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG^®-tag.
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:	Binds to human HVEM and human and mouse TNF-R1 and TNF-R2.
BIOLOGICAL ACTIVITY:	Kills human TNF-R1 positive cells.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles.

General Information

Lymphotoxin-α (LTα, TNF-β) is a 25 kDa type II soluble protein belonging to the TNF family. It is expressed as a trimer (LTα3), or with lymphotoxin-β (LTα1β2 or LTα2β1). LTα3 interacts with 3 different members of the TNF-receptor superfamily: HVEM (Prod. No. ALX-522-017), TNF-R1 (Prod. No. ALX-522-013) and TNF-R2 (Prod. No. ALX-522-014). LTα3 is expressed by activated T and B lymphocytes and is a pro-apoptotic cytokine, a pluripotent mediator of inflammtory and immune defense mechanisms, and moreover it plays an important role in regulating the generation of the peripheral lymphoid system.

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P01374: TNF-β (human) (precursor)
AfCS Signalling Gateway link A001438: TNF-β (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

HVEM & LIGHT / LT-betaR / DcR3 / Related Products • Recombinant Proteins / Fusion Proteins

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