ALEXIS Biochemicals: Capsazepine

ALX-550-145

Revised 08-Feb-08

Capsazepine
SYNONYMS	N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-145-M005		5 mg	60.00 USD
ALX-550-145-M025		25 mg	240.00 USD

Product Specification

FORMULA:	C₁₉H₂₁ClN₂O₂S
MW:	376.9
CAS NUMBER:	138977-28-3
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Analog of capsaicin (Prod. No. ALX-550-066) that acts as a capsaicin antagonist. Increases intracellular Ca²⁺ levels.

Product Specific Literature References

Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro: L. Urban & A. Dray; Neurosci. Lett. 134, 9 (1991) Abstract
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin: S. Bevan, et al.; Br. J. Pharmacol. 107, 544 (1992) Abstract
A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens: C.A. Maggi, et al.; Br. J. Pharmacol. 108, 801 (1993) Abstract
Inhibition by capsazepine of resiniferatoxin- and capsaicin-induced contractions of guinea pig trachea: J.L. Ellis & B.J. Undem; J. Pharmacol. Exp. Ther. 268, 85 (1994) Abstract
The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin: C.S. Walpole, et al.; J. Med. Chem. 37, 1942 (1994) Abstract
Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting I(h): A.M. Ray, et al.; J. Neurosci. 23, 10146 (2003) Abstract
Characterization of the human HCN1 channel and its inhibition by capsazepine: C.H. Gill, et al.; Br. J. Pharmacol. 143, 411 (2004) Abstract
Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel: H. Yamamura, et al.; J. Biol. Chem. 279, 44483 (2004) Abstract
Effect of capsazepine on cytosolic Ca(2+) levels and proliferation of human prostate cancer cells: J.K. Huang, et al.; Toxicol. In Vitro 20, 567 (2006) Abstract

Further Categories Containing This Product:

TRPV1 Agonists and Antagonists / Related Products

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