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ALX-106-037 Revised 09-Oct-07
L-Cycloserine
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SYNONYMS S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-037-M025   25 mg 50.00 USD Add To Cart
ALX-106-037-M100   100 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 339-72-0; 4834-58-6
MERCK INDEX: 14: 2751
RTECS: NY2976000
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo: K.S. Sundaram & M. Lev; J. Neurochem. 42, 577 (1984) Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine: R.D. Williams, et al.; J. Lipid Res. 28, 1478 (1987) Abstract; Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes: G.B. Watson, et al.; Brain Res. 510, 158 (1990) Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain: I.P. Chessell, et al.; Brain Res. 565, 345 (1991) Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta 1083, 101 (1991) Abstract
Further Categories Containing This Product:
Special Amino Acids • Excitatory Amino Acids • NMDA Receptors / Related Products
 
 
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