ALEXIS Biochemicals: Ac-IETD-pNA

ALX-260-045

Revised 25-Nov-08

Ac-IETD-pNA
SYNONYMS	Caspase-8 Substrate (Chromogenic) Granzyme B Substrate (Chromogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-045-M001		1 mg	22.00 USD
ALX-260-045-M005		5 mg	83.00 USD

Product Specification

SEQUENCE:	Ac-Ile-Glu-Thr-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:	C₂₇H₃₈N₆O₁₂
MW:	638.6
PEPTIDE CONTENT:	70-90%
PURITY:	98% (HPLC)
APPEARANCE:	White to yellow powder.
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in DMSO. Dilute with buffer, pH 7.0-7.5.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.

Product Description

Chromogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.

Product Specific Literature References

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Abstract; Full Text
Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells: S.H. Kwon, et al.; J. Biol. Chem. 277, 2073 (2002) Abstract; Full Text
Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes: C.A. Belmokhtar, et al.; J. Biol. Chem. 278, 29571 (2003) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION

λmax of pNA is 400nm.

Further Categories Containing This Product:

Granzyme Substrates

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