ALEXIS Biochemicals: O6-Benzylguanine

ALX-480-019

Revised 12-Feb-08

O6-Benzylguanine
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	DNA & RNA Methyl & Alkyl Transferases/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-019-M010		10 mg	30.00 USD
ALX-480-019-M050		50 mg	95.00 USD

Product Specification

FORMULA:	C₁₂H₁₁N₅O
MW:	241.2
CAS NUMBER:	19916-73-5
PURITY:	≥99%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in methanol (20mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Effective substrate and efficient inactivator of DNA alkyltransferase.

Product Specific Literature References

Activation of human O6-alkylguanine-DNA alkyltransferase by DNA: K. Goodtzova, et al.; Biochemistry 33, 8385 (1994) Abstract
Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine: R.H. Elder, et al.; Biochem. J. 298, 231 (1994) Abstract
O6-benzylguanine and its role in chemotherapy: M.E. Dolan & A.E. Pegg; Cancer Res. 3, 837 (1997) Abstract
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo: E.L. Kreklau, et al.; Pharmacol. Exp. Ther. 291, 1269 (1999) Abstract

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