© 2008 Alexis Corporation
ALX-380-100
Revised 14-Mar-08
Leptomycin B
SYNONYMS
LMB
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
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ALX-380-100-C100
100 µg
95.00 USD
Product Specification
FORMULA:
C
33
H
48
O
6
MW:
540.7
CAS NUMBER:
87081-35-4
SOURCE/HOST:
Isolated from
Streptomyces sp
.
CONCENTRATION:
0.2mg/ml
PURITY:
≥98% (HPLC)
FORMULATION:
Liquid. In 100% ethanol.
SOLUBILITY:
Soluble in methanol or 100% ethanol; insoluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
HAZARD:
TOXIC. FLAMMABLE.
Product Description
Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, Iκb, MPF and PKA.
Product Specific Literature References
Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization:
T. Hamamoto, et al.; J. Antibiot. (Tokyo)
36
, 639 (1983)
Abstract
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms:
T. Meissner, et al.; FEBS Lett.
576
, 27 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Please also see our Product Flyer
"LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport"
.
Further Categories Containing This Product:
CDK & Cyclin Inhibitors
•
Nuclear Envelope & Nuclear Transport
•
Antibiotics for Cell Cycle Research
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