© 2008 Alexis Corporation
ALX-270-391
Revised 18-Jul-07
CGP 74514A
SYNONYMS
N-(
cis
-
2-Aminocyclohexyl)-N-(3-chlorophenyl)-9-ethyl-9
H
-purine-2,6-diamine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-391-M001
1 mg
35.00 USD
ALX-270-391-M005
5 mg
70.00 USD
ALX-270-391-M025
25 mg
280.00 USD
Product Specification
FORMULA:
C
19
H
24
ClN
7
MW:
385.9
PURITY:
≥95%
APPEARANCE:
White to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Cell permeable, potent and selective inhibitor of CDK1/cyclin B (IC
50
=25nM). Reported to affect the activities of other kinases only at much higher concentrations: PKCα (IC
50
=6.1µM), PKA (IC
50
=125µM) and EGFR (IC
50
>10µM). Induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3µM).
Product Specific Literature References
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors
:
P. Imbach, et al.; Bioorg. Med. Chem. Lett.
9
, 91 (1999)
Abstract
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
:
C. Yu, et al.; Cancer Res.
63
, 1822 (2003)
Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
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