ALEXIS Biochemicals: Polyclonal Antibody to CLOCK (mouse) (CT)

ALX-210-244

Revised 20-Oct-04

Polyclonal Antibody to CLOCK (mouse) (CT)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Circadian Transcriptional Regulators / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-244-R200		200 µl	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
SOURCE/HOST:	From rabbit.
FORMULATION:	100µg of epitope affinity purified rabbit IgG (1.9mg/ml) with 1.0mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN:	Synthetic peptide corresponding to aa 394-411 of mouse CLOCK.
SPECIFICITY:	Recognizes mouse CLOCK. Detects a band of ~100kDa by Western blot.
APPLICATION:	Western Blot (1:200)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
BLOCKING PEPTIDE:	For Blocking Peptide see Prod. No. ALX-153-032.

Product Description

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein mediated autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.

Further Categories Containing This Product:

Polyclonal Antibodies

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