ALEXIS Biochemicals: H-Trp-Glu-OH

ALX-190-001

Revised 20-Jun-08

H-Trp-Glu-OH
SYNONYMS	H-WE-OH G3335
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PARP Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-190-001-M050		50 mg	80.00 USD

Product Specification

FORMULA:	C₁₆H₁₉N₃O₅
MW:	333.3
CAS NUMBER:	36099-95-3
PURITY:	≥97%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Cell permeable, selective and reversible PPARγ antagonist. Has been shown to inhibit the agonist activity of rosiglitazone (Prod. No. ALX-350-125) in a dose-dependent manner (IC₅₀=31.9µM).

Product Specific Literature References

The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation: F. Ye, et al.; Chembiochem. 7, 74 (2006) Abstract
The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator activated receptors: N. B. Mettu, et al.; Mol. Endocrinol. 21, 2361 (2007) Abstract; Full Text

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