© 2008 Alexis Corporation
ALX-270-390
Revised 09-Jan-08
Bohemine
SYNONYMS
6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-390-M001
1 mg
40.00 USD
ALX-270-390-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
18
H
24
N
6
O
MW:
340.4
CAS NUMBER:
189232-42-6
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture.
Product Description
Cell permeable inhibitor of CDK1 (IC
50
=1.1µM) and CD2 (IC
50
=600nM). Arrests cell cycle in the G
1
/S boundary and activates mature bovine oocytes.
Product Specific Literature References
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds
:
L. Havlicek, et al.; J. Med. Chem.
40
, 408 (1997)
Abstract
Treatment of Vicia faba root tip cells with specific inhibitors to cyclin-dependent kinases leads to abnormal spindle formation
:
P. Binarova, et al.; Plant J.
16
, 697 (1998)
Abstract
Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases
:
R. Alberio, et al.; Mol. Reprod. Dev.
55
, 422 (2000)
Abstract
Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine
:
H. Kovarova, et al.; Electrophoresis
21
, 3757 (2000)
Abstract
In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route
:
Z. Chmela, et al.; Drug. Metab. Dispos.
29
, 326 (2001)
Abstract
;
Full Text
Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases:
K. Vermeulen, et al.; Leukemia
16
, 299 (2002)
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors/Related Products
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