ALEXIS Biochemicals: 5-Aza-2'-deoxycytidine

ALX-480-096

Revised 18-Aug-08

5-Aza-2'-deoxycytidine
SYNONYMS	5-Aza-CdR 5-Aza-dC 5-Deoxy-2'-azacytidine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Nucleobases

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-096-M005		5 mg	240.00 USD

Product Specification

FORMULA:	C₈H₁₂N₄O₄
MW:	228.2
CAS NUMBER:	2353-33-5
RTECS:	XZ3012000
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	25mg/ml soluble in DMSO or 50% acetic acid; 1mg/ml soluble in methanol. (Warming may be required to achieve complete solubilization.)
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
HAZARD:	HARMFUL.

Product Description

Inhibitor of DNA methyltransferase. Restores mRNA and protein expression of caspase-8 and TRAIL (tumor necrosis factor-related apoptosis inducing ligand) sensitivity of resistant cell lines. Enhances apoptosis induced by HDAC (histone deacetylase) inhibitors.

Product Specific Literature References

Incorporation of a potent antileukemic agent, 5-aza-2'-deoxycytidine, into DNA of cells from leukemic mice: J. Vesely and A. Cihak; Cancer Res. 37, 3684 (1977) Abstract
Cellular differentiation, cytidine analogs and DNA methylation: P.A. Jones and S.M. Taylor; Cell 20, 85 (1980) Abstract
The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes: T. Haaf; Pharmacol. Ther. 65, 19 (1995) Abstract
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis: S. Hopkins-Donaldson, et al.; Cancer Res. 60, 4315 (2000) Abstract; Full Text
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression: A. Eggert, et al.; Cancer Res. 61, 1314 (2001) Abstract; Full Text
5-Aza-2'-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation: S. Takebayashi, et al.; BBRC 288, 921 (2001) Abstract
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors: W.G. Zhu, et al.; Cancer Res. 61, 1327 (2001) Abstract; Full Text

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DNA & RNA Methyl & Alkyl Transferases / Related Products

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