ALEXIS Biochemicals: Patulin

ALX-270-111

Revised 31-Jul-08

Patulin
SYNONYMS	4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one Clairformin Clavacin Clavatin Claviformin Leucopin Mycoin C3 Mycosin Penicidin Terinin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-111-M001		1 mg	20.00 USD
ALX-270-111-M005		5 mg	80.00 USD
ALX-270-111-M025		25 mg	320.00 USD

Product Specification

FORMULA:	C₇H₆O₄
MW:	154.1
CAS NUMBER:	149-29-1
MERCK INDEX:	14: 7053
RTECS:	LV2625000
SOURCE/HOST:	Isolated from Penicillium expansum.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water, 100% ethanol, ethyl acetate or DMSO (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE CARCINOGENIC. TOXIC.

Product Description

Inhibitor of protein farnesylation in a cell free assay. Inhibits incorporation of tritiated mevalonate into proteins in whole cells. Mycotoxin with anti-bacterial, potassium uptake inhibitory and possibly carcinogenic activities. Known contaminant of spoiled apples.

Product Specific Literature References

M. Birkinshaw, et al.; Lancet 245, 625 (1943)
J. Kahn; J. Pharmacol. Exp. Ther. 121, 234 (1957)
IARC Monographs 10, 205 (1976)
Chronology of patulin-induced alterations in membrane function of cultured renal cells, LLC-PK: R.T. Riley, et al.; Toxicol. Appl. Pharmacol. 102, 128 (1990) Abstract
Inhibition of protein prenylation by patulin: S. Miura, et al.; FEBS Lett. 318, 88 (1993) Abstract
Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin: E. Pfeiffer, et al.; Carcinogenesis 19, 1313 (1998) Abstract
Hplc detection of patulin in apple juice with GC/MS confirmation of patulin identity: J.A. Roach, et al.; Adv. Exp. Med. Biol. 504, 135 (2002), Review Abstract

Further Categories Containing This Product:

Mycotoxins • Farnesylation / Isoprenylation Reagents

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