ALEXIS Biochemicals: Aaptamine

ALX-350-104

Revised 10-May-07

Aaptamine
SYNONYMS	8,9-Dimethoxy-1H-benzo[de][1,6]naphtyridine
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Toxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-104-M001		1 mg	90.00 USD

Product Specification

FORMULA:	C₁₃H₁₂N₂O₂
MW:	228.3
CAS NUMBER:	85547-22-4
SOURCE/HOST:	Isolated from the sponge Aaptos aaptos.
PURITY:	≥97%
APPEARANCE:	Oil.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Competitive antagonist of α-adrenoceptors in vascular smooth muscle cells. Inhibits cancer cell growth.

Product Specific Literature References

Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle: Y. Ohizumi, et al.; J. Pharm. Pharmacol. 36, 785 (1984) Abstract
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine: G.R. Pettit, et al.; J. Org. Chem. 69, 2251 (2004) Abstract
Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner: S. Aoki, et al.; BBRC 342, 101 (2006) Abstract

Further Categories Containing This Product:

Alkaloids • Antitumor Agents (Anti-proliferative) • Adrenergics & Adrenergic Receptors/Related Products • Natural Products - Antitumor Reagents

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