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ALX-270-420 Revised 11-Sep-07
ABH . ammonium salt
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SYNONYMS 2(S)-Amino-6-boronohexanoic acid . NH4
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Arginine & Arginases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-420-M001   1 mg 60.00 USD Add To Cart
ALX-270-420-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C6H13BNO4 . NH4
MW: 174.0 . 18.0
PURITY: ≥95.0% (1H-NMR)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY:

Solutions are stable for 6 months when stored at -20°C.
HANDLING: Hygroscopic. After reconstitution, prepare aliquots and store at -20°C.

Product Description
Potent and specific inhibitor of arginase. Does not inhibit NO synthases.
Product Specific Literature References
Inhibition of Mn2+ 2-arginase by borate leads to the design of a transition state analog inhibitor, 2(S)-amino-6-boronohexanoic acid: R. Baggio, et al.; J. Am. Chem. Soc. 119, 8107 (1997)
Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor: R. Baggio, et al.; J. Pharmacol. Exp. Ther. 290, 1409 (1999) Abstract; Full Text
Arginase-boronic acid complex highlights a physiological role in erectile function: J.D. Cox, et al.; Nat. Struct. Biol. 6, 1043 (1999) Abstract
Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori and D.E. Ash; Biochemistry (Mosc). 40, 9356 (2001) Abstract
Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction: T.J. Bivalacqua, et al.; BBRC 283, 923 (2001) Abstract
Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans: P. Stickings, et al.; Nitric Oxide 7, 289 (2002) Abstract
Arginase and autoimmune inflammation in the central nervous system: L. Xu, et al.; Immunology 110, 141 (2003) Abstract; Full Text
Role of arginase in the male and female sexual arousal response: N.N. Kim, et al.; J. Nutr. 134, 2873S (2004) Abstract; Full Text
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS 102, 13058 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Note: Contains ~14% ammonium chloride. This does not affect activity, but must be taken into account for calculation of concentrations.
 
 
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