ALEXIS Biochemicals: Monoclonal Antibody to Proteinase Inhibitor 9 (human) (7D8)

ALX-804-595

Revised 16-Jul-07

Monoclonal Antibody to Proteinase Inhibitor 9 (human) (7D8)
SYNONYMS	anti-PI9 (human) MAb (7D8) anti-Serpin B9 (human) MAb (7D8) anti-CAP3 (human) MAb (7D8) anti-Cytoplasmic Antiproteinase 3 (human) MAb (7D8)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Proteinase Inhibitor 9 [PI9] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-595-C100		100 µg	280.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	7D8
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:	Recombinant PI9 (proteinase inhibitor 9).
SPECIFICITY:	Recognizes human PI9. Does not cross-react with mouse or pig PI9.
APPLICATION:	Flow Cytometry Immunohistochemistry (frozen sections; paraffin sections require antigen retrieval using heat treatment methods prior to staining) Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for 12 months when stored at +4°C.

Product Specific Literature References

Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction: C.E. Hirst, et al.; Mol. Hum. Reprod. 7, 1133 (2001) Abstract; Full Text
The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency: C.E. Hirst, et al.; J. Immunol. 170, 805 (2003) Abstract

General Information

The human intracellular serpin proteinase inhibitor 9 (PI9) is the only human protein able to inhibit the activity of the serine protease granzyme B. Granzyme B is expressed by cytotoxic lymphocytes and induces rapid target cell apoptosis.

General Literature References

Human proteinase inhibitor 9 (PI9) is a potent inhibitor of subtilisin A: J.R. Dahlen, et al.; BBRC 238, 329 (1997) Abstract
Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway: C.H. Bird, et al.; Mol. Cell. Biol. 18, 6387 (1998) Abstract
Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9: R.R. Annand, et al.; Biochem. J. 342 Pt 3, 655 (1999) Abstract; Full Text
Inhibition of neutrophil elastase by recombinant human proteinase inhibitor 9: J.R. Dahlen, et al.; Biochim. Biophys. Acta 1451, 233 (1999) Abstract

Further Categories Containing This Product:

Monoclonal Antibodies

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