© 2008 Alexis Corporation
ALX-460-007
Revised 02-Feb-07
Menadione
SYNONYMS
Vitamin K
3
2-Methyl-1,4-naphthoquinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Vitamins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-460-007-G010
10 g
10.00 USD
Product Specification
FORMULA:
C
11
H
8
O
2
MW:
172.2
CAS NUMBER:
58-27-5
MERCK INDEX:
14:
5831
RTECS:
QL9100000
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow crystals.
SOLUBILITY:
Soluble in 96% ethanol (16mg/ml) or DMSO (1mg/ml); almost insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
HAZARD:
HARMFUL.
Product Description
Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.
Product Specific Literature References
Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase:
F.Y. Wu and T.P.; Eur. J. Cancer
35
, 1388 (1999)
Abstract
Apoptosis-inducing activity of vitamin C and vitamin K:
H. Sakagami, et al.; Cell Mol. Biol.
46
, 129 (2000)
Abstract
Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells:
L.K. Sun, et al.; J. Neurooncol.
47
, 31 (2000)
Abstract
Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines:
H. Okayasu, et al.; Anticancer Res.
21
, 2387 (2001)
Abstract
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade:
L.O. Klotz, et al.; Cancer Res.
62
, 4922 (2002)
Abstract
;
Full Text
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy:
J. Mauzeroll, et al.; PNAS
101
, 17582 (2004)
Abstract
;
Full Text
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells:
D.N. Criddle, et al.; J. Biol. Chem.
281
, 40485 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation)
•
Antitumor Agents (Apoptosis Inducers)
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
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