© 2008 Alexis Corporation
ALX-300-150
Revised 11-Oct-07
Oleoylethanolamide
SYNONYMS
N-(2-Hydroxyethyl)-9Z-octadecenamide
OEA
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
TRPV1 Agonists and Antagonists / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-300-150-M005
5 mg
30.00 USD
Product Specification
FORMULA:
C
20
H
39
NO
2
MW:
325.5
CAS NUMBER:
111-58-0
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Activates TRPV1. Does not activate cannabinoid receptors (CB) but is a PPARα agonist (EC
50
=120nM)
in vitro
and
in vivo
; induces satiety through activation of PPARα. Inhibits ceramidase.
Product Specific Literature References
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor:
L. Hanus, et al.; J. Med. Chem.
36
, 3032 (1993)
Abstract
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation
:
E. Coroneos, et al.; J. Biol. Chem.
270
, 23305 (1995)
Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides:
J. Barg, et al.; Eur. J. Pharmacol.
287
, 145 (1995)
Abstract
A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
:
R. Gomez, et al.; J. Neurosci.
22
, 9612 (2002)
Abstract
Activation of TRPV1 by the satiety factor oleoylethanolamide
:
G.P. Ahern; J. Biol. Chem.
278
, 30429 (2003)
Abstract
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
:
J. Fu, et al.; Nature
425
, 90 (2003)
Abstract
Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor PPAR-alpha
:
M. Guzman, et al.; J. Biol. Chem.
279
, 27849 (2004)
Further Categories Containing This Product:
Anandamide & Anandamide Analogs
•
PPAR Agonists
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