ALEXIS Biochemicals: Phorbol 12,13-diacetate

ALX-445-003

Revised 08-Apr-08

Phorbol 12,13-diacetate
SYNONYMS	PDA
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Phorbols / Phorbol Esters

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-445-003-M001		1 mg	20.00 USD
ALX-445-003-M005		5 mg	65.00 USD

Product Specification

FORMULA:	C₂₄H₃₂O₈
MW:	448.5
CAS NUMBER:	24928-15-2
PURITY:	≥99%
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HIGHLY IRRITANT. TUMOR PROMOTER.

Product Description

Less potent than phorbol 12,13-dibutyrate (PDBu) (Prod. No. ALX-445-001), but also less hydrophobic.

Product Specific Literature References

Modulation of high-threshold Ca current and spontaneous postsynaptic transient currents by phorbol 12,13-diacetate, 1-(5-isoquinolinesulfonyl)-2-methyl piperazine (H-7), and monosialoganglioside (GM1) in CA1 pyramidal neurons of rat hippocampus in vitro: N. Agopyan, et al.; Hippocampus 3, 67 (1993) Abstract
Effects of phorbol 12,13-diacetate on human isolated bronchus: B. Sarria, et al.; Eur. J. Pharmacol. 399, 65 (2000) Abstract
Characterization of phorbol esters activity on individual mammalian protein kinase C isoforms, using the yeast phenotypic assay: L. Saraiva, et al.; Eur. J. Pharmacol. 491, 101 (2004) Abstract

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