ALEXIS Biochemicals: MCD Peptide

ALX-162-002

Revised 09-Oct-08

MCD Peptide
SYNONYMS	Mast Cell Degranulating Peptide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-162-002-MC05		0.5 mg	360.00 USD

Product Specification

SEQUENCE:	H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH₂ (Disulfide bonds between Cys³-Cys¹⁵ and Cys⁵-Cys¹⁹)
FORMULA:	C₁₁₀H₁₉₂N₄₀O₂₄S₄
MW:	2587.2
CAS NUMBER:	83856-13-7
SOURCE/HOST:	Synthetic. Originally isolated from Apis mellifera.
PURITY:	≥98%
APPEARANCE:	Lyophilized.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent anti-inflammatory agent and strong mediator of mast cell degranulation and histamine release. Neurotoxin and voltage-dependent K⁺channel blocker. Inhibits the ADP-ribosylation of the small GTP-binding proteins rho.

Product Specific Literature References

Bee and wasp venoms: E. Haberman; Science 177, 314 (1972) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Mast cell degranulating peptide: a multi-functional neurotoxin: M.R. Ziai, et al.; J. Pharm. Pharmacol. 42, 457 (1990), Review Abstract
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992) Abstract

Further Categories Containing This Product:

Peptides • K+ Channel Blockers & Inhibitors • Natural Products - Anti-inflammatory Agents

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