© 2008 Alexis Corporation
ALX-210-537
Revised 10-Apr-08
Polyclonal Antibody to CD51
SYNONYMS
anti-αV Integrin PAb
Polyclonal Antibody to Vitronectin Receptor (α Subunit)
anti-Vitronectin Receptor (α Subunit) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-537-R100
100 µl
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Goat
Sheep
Dog
Pig
Monkey
SOURCE/HOST:
From rabbit.
PURITY:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain).
SPECIFICITY:
Recognizes cytoplasmic domain of CD51 of all species.
APPLICATION:
ELISA
Immunocytochemistry (1:1’000)
Immunohistochemistry (1:1’000)
Immunoprecipitation (5µl per 5x10
6
cells)
Western Blot (1:5’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development:
E. Hirsch, et al.; Dev. Dyn.
201
, 108 (1994)
Abstract
General Information
CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.
Further Categories Containing This Product:
Angiogenesis Other Products
•
Polyclonal Antibodies
•
Bone Metabolism Other Products
•
Adhesion Molecules & Receptors Antibodies
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