ALEXIS Biochemicals: Pefloxacin . mesylate . dihydrate

ALX-380-298

Revised 15-Apr-08

Pefloxacin . mesylate . dihydrate
SYNONYMS	1-Ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid . monomethanesulfonate . dihydrate

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-298-G005		5 g	30.00 USD

Product Specification

FORMULA:	C₁₇H₂₀FN₃O₃ . CH₄O₃S . 2H₂O
MW:	333.4 . 96.1 . 36.0
CAS NUMBER:	149676-40-4
MERCK INDEX:	14: 7066
RTECS:	VB2002200
PURITY:	≥98%
APPEARANCE:	White to yellow crystalline solid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Fluoroquinolone antibacterial agent. Analog of norfloxacin (Prod. No. ALX-380-295). Prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse). Highly effective against Staphylococcus aureus, E. coli, other enterobacteria and Pseudomonas aeruginosa. Excellent effcectivity against Gram-negative bacteria, also effective against Gram-positive bacteria.

Product Specific Literature References

Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans: G. Montay, et al.; Antimicrob. Agents Chemother. 25, 463 (1984) Abstract; Full Text
Activity of pefloxacin and thirteen other antimicrobial agents in vitro against isolates from hospital and genitourinary infections: B.M. Jones, et al.; J. Antimicrob. Chemother. 17, 739 (1986) Abstract
In vitro activity of pefloxacin against gram-negative and gram-positive bacteria in comparison with other antibiotics: E. Debbia, et al.; Chemioterapia 6, 319 (1987) Abstract
Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives: H. Kondo, et al.; J. Med. Chem. 31, 221 (1988) Abstract
In vitro effects of ciprofloxacin and pefloxacin on growth of normal human hematopoietic progenitor cells and on leukemic cell lines: E. Somekh, et al.; J. Pharmacol. Exp. Ther. 248, 415 (1989) Abstract
Binding interactions of pefloxacin mesylate with bovine lactoferrin and human serum albumin: J.C. Fan, et al.; J. Zhejiang Univ. Sci. B. 7, 452 (2006) Abstract; Full Text
Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals: K. Basavaiah, et al.; Acta Pharm. 57, 221 (2007) Abstract

Further Categories Containing This Product:

Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors

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