ALEXIS Biochemicals: Bohemine

ALX-270-390

Revised 09-Jan-08

Bohemine
SYNONYMS	6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-390-M001		1 mg	40.00 USD
ALX-270-390-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₁₈H₂₄N₆O
MW:	340.4
CAS NUMBER:	189232-42-6
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from moisture.

Product Description

Cell permeable inhibitor of CDK1 (IC₅₀=1.1µM) and CD2 (IC₅₀=600nM). Arrests cell cycle in the G₁/S boundary and activates mature bovine oocytes.

Product Specific Literature References

Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem. 40, 408 (1997) Abstract
Treatment of Vicia faba root tip cells with specific inhibitors to cyclin-dependent kinases leads to abnormal spindle formation: P. Binarova, et al.; Plant J. 16, 697 (1998) Abstract
Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases: R. Alberio, et al.; Mol. Reprod. Dev. 55, 422 (2000) Abstract
Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine: H. Kovarova, et al.; Electrophoresis 21, 3757 (2000) Abstract
In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route: Z. Chmela, et al.; Drug. Metab. Dispos. 29, 326 (2001) Abstract; Full Text
Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases: K. Vermeulen, et al.; Leukemia 16, 299 (2002)

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Cell Cycle Blockers & Inhibitors/Related Products

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