ALEXIS Biochemicals: Acrolein

ALX-280-016

Revised 13-Feb-08

Acrolein
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-280-016-L010		10 ml	110.00 USD

Product Specification

FORMULA:	C₃H₄O
MW:	56.1
CAS NUMBER:	107-02-8
MERCK INDEX:	14: 128
RTECS:	AS1050000
PURITY:	≥95% (GC)
APPEARANCE:	Clear to yellow liquid.
PURITY DETAIL:	≥99% (as anhydrous). Stabilized with ~0.2% hydroquinone and ~3% water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Unstable. Very reactive with acids, amines, alkalis, sulfur dioxide, metal salts, oxidants, thiourea, dimethylamine, or weak acid conditions such as nitrogen or carbon oxide gases. Reactions may be very rapid and violent.
HANDLING:	Keep away from heat, sources of ignition and incompatibles such as oxidizing agents.
HAZARD:	FLAMMABLE VERY TOXIC.
IDENTITY:	Determined by ¹H-NMR.

Product Description

Highly electrophilic α,β-unsaturated aldehyde to which humans are exposed in a variety of environmental situations (particularly as a component of smoke). As a metabolite of cyclophosphamide, acrolein is a major factor in the toxicity and perhaps the therapeutic activity of this important anticancer agent. Reduces NF-κB activation through the formation of conjugates with NF-κB.

Product Specific Literature References

Acrolein causes inhibitor kappaB-independent decreases in nuclear factor kappaB activation in human lung adenocarcinoma (A549) cells: N.D. Horton, et al.; J. Biol. Chem. 274, 9200 (1999) Abstract; Full Text

General Literature References

The molecular effects of acrolein: J.P. Kehrer & S.S. Biswal; Toxicol. Sci. 57, 6 (2000) Abstract

Further Categories Containing This Product:

Antitumor Agents (Enzyme Inhibitors)

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