ALEXIS Biochemicals: Polyclonal Antibody to PALB2 (human) (AT126)

ALX-210-951

Revised 23-Apr-08

Polyclonal Antibody to PALB2 (human) (AT126)
SYNONYMS	anti-Partner and Localizer of BRCA2 (human) PAb (AT126) anti-FANCN (human) PAb (AT126)
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	BRCA1 & BRCA2/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-951-C100		100 µg	360.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SOURCE/HOST:	From rabbit.
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein A-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human PALB2 (aa 1-200).
SPECIFICITY:	Recognizes human PALB2.
APPLICATION:	Immunoprecipitation (weak (1:100)) Western Blot (1:1´000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

General Information

PALB2 (partner and localizer of BRCA2; FANCN) has been identified as a new BRCA2 (breast cancer type 2) binding protein. PALB2 colocalizes with BRCA2 in nuclear foci, promotes its stability in key nuclear structurs (chromatin and nuclear matrix) and enables its recombinational repair and checkpoint functions. Mutations in the gene of PALB2 may contribute to breast cancer development (as well as prostate cancer). Mutations in PALB2 also cause Fanconi anemia.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2: B. Xia, et al.; Mol. Cell 22, 719 (2006) Abstract
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene: N. Rahman, et al.; Nat. Genet. 39, 165 (2007) Abstract
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2: B. Xia, et al.; Nat. Genet. 39, 159 (2007) Abstract
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins: W. Wang; Nat. Rev. Genet. 8, 735 (2007) Abstract
The Fanconi anemia pathway and ubiquitin: C. Jacquemont & T. Taniguchi; BMC Biochem. 8 Suppl 1, S10 (2007) Abstract; Full Text

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Polyclonal Antibodies

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