© 2008 Alexis Corporation
ALX-270-388
Revised 18-Jul-07
Benfluorene
SYNONYMS
Ethyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-
b
])pyridine-3-carboxylate
1-Aza-9-oxafluorene 5a
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-388-M001
1 mg
70.00 USD
ALX-270-388-M005
5 mg
280.00 USD
Product Specification
FORMULA:
C
20
H
15
NO
4
MW:
333.3
PURITY:
≥95% (HPLC)
APPEARANCE:
Brownish powder.
SOLUBILITY:
Soluble in DMSO or 100% ethanol. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Selective inhibitor of CDK1 (IC
50
=28.8µM) with P-glycoprotein-modulating properties (inhibitory activity ratio 9.5 at 7µM). Weakly inhibits CDK5 (6% inhibition at 10µM) with no effect on CDK2 and CDK4 (IC
50
>100µM).
Product Specific Literature References
Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties
:
K. Brachwitz, et al.; J. Med. Chem.
46
, 876 (2003)
Abstract
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