ALEXIS Biochemicals: Monoclonal Antibody to CHOP (9C8)

ALX-804-551

Revised 12-Nov-07

Monoclonal Antibody to CHOP (9C8)
SYNONYMS	anti-C/EBP Homology Protein MAb (9C8) anti-GADD153 MAb (9C8) anti-Growth Arrest and DNA Damage Inducible Protein 153 MAb (9C8)
PRODUCT LINE	Stress & Heat Shock Proteins
PRODUCT CATEGORY	Endoplasmatic Reticulum Stress

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-551-C100		100 µg	379.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	9C8
ISOTYPE:	Mouse IgG2b
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:	Recombinant mouse CHOP (C/EBP homology protein).
SPECIFICITY:	Recognizes an N-terminal epitope of human and mouse CHOP. Detects a band of ~31kDa by Western blot.
APPLICATION:	Immunoprecipitation Western Blot (1µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153): N. Batchvarova, et al.; EMBO J. 14, 4654 (1995) Abstract
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153): X.Z. Wang, et al.; Mol. Cell. Biol. 16, 4273 (1996) Abstract; Full Text
Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins: S. Saisanit and X.H. Sun; Mol. Cell. Biol. 17, 844 (1997) Abstract; Full Text
Identification of novel stress-induced genes downstream of chop: X.Z. Wang, et al.; EMBO J. 17, 3619 (1998) Abstract; Full Text
Cloning of mammalian Ire1 reveals diversity in the ER stress responses: X.Z. Wang, et al.; EMBO J. 17, 5708 (1998) Abstract; Full Text
Induction of a secreted protein by the myxoid liposarcoma oncogene: M. Kuroda, et al.; PNAS 96, 5025 (1999) Abstract; Full Text
CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI: J. Sok, et al.; Mol. Cell. Biol. 19, 495 (1999) Abstract; Full Text

General Information

CHOP is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP α and β. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP-CHOP dimer gains binding activity to other non-classical C/EBP stress related targets.
Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of CHOP inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.

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