ALEXIS Biochemicals: Farnesyltransferase Inhibitor

ALX-290-005

Revised 10-Aug-05

Farnesyltransferase Inhibitor
SYNONYMS	B581
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Farnesylation / Isoprenylation Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-290-005-M001		1 mg	85.00 USD
ALX-290-005-M005		5 mg	320.00 USD

Product Specification

SEQUENCE:	N-[(2S)-((2R)-Amino-3-mercaptopropylamino)-3-methylbutyl]-Phe-Met-OH
FORMULA:	C₂₂H₃₈N₄O₃S₂
MW:	470.7
PURITY:	≥96%
APPEARANCE:	White powder.
SOLUBILITY:	Soluble in water or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.

Product Description

Stable, membrane permeable inhibitor of farnesyltransferase. Has 30-fold higher selectivity for farnesyltransferase over geranylgeranyltransferase. Potential anticancer drug.

Product Specific Literature References

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells: A.M. Garcia, et al.; J. Biol. Chem. 268, 18415 (1993) Abstract; Full Text

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