ALEXIS Biochemicals: Leupeptin (synthetic)

ALX-260-009

Revised 19-Dec-07

Leupeptin (synthetic)
SYNONYMS	Acetyl-L-leucyl-L-leucyl-L-argininal . sulfate
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Cathepsin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-009-M005		5 mg	40.00 USD
ALX-260-009-M025		25 mg	95.00 USD
ALX-260-009-M100		100 mg	320.00 USD

Product Specification

FORMULA:	C₂₀H₃₈N₆O₄ . 0.5 H₂SO₄
MW:	426.6 . 49.0
CAS NUMBER:	103476-89-7
MERCK INDEX:	14: 5456
SOURCE/HOST:	Synthetic.
PURITY:	≥95%
APPEARANCE:	Lyophilized.
SOLUBILITY:	Soluble in water, methanol and 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Competitive and reversible inhibitor of serine and cysteine proteinases like calpain, porcine kallikrein, trypsin, plasmin, papain and cathepsin B. Does not inhibit chymotrypsin and thrombin. Also known to inhibit activation-induced programmed cell death and restoration of defective immune responses of HIV⁺ donors.

Product Specific Literature References

Isolation and characterization of leupeptins produced by Actinomycetes: S. Kondo, et al.; Chem. Pharm. Bull. 17, 1896 (1969) Abstract
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts: J.P. Montenez, et al.; Toxicol. Lett. 73, 201 (1994) Abstract
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors: A. Sarin, et al.; J. Immunol. 153, 862 (1994) Abstract
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin: M.A. Belaud-Rotureau, et al.; Cell Death Differ. 6, 788 (1999) Abstract

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