ALEXIS Biochemicals: α-Conotoxin SI

ALX-630-049

Revised 10-Oct-08

α-Conotoxin SI
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-049-C500		500 µg	480.00 USD

Product Specification

SEQUENCE:	H-Ile-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Pro-Lys-Tyr-Ser-Cys-NH₂ (Disulfide bonds between Cys²-Cys⁷and Cys³-Cys¹³)
FORMULA:	C₅₅H₈₃N₁₆O₁₆S₄
MW:	1352.6
SOURCE/HOST:	Synthetic. Originally isolated from Conus striatus.
PURITY:	≥96%
APPEARANCE:	Lyophilized.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Neurotoxin. Postsynaptic inhibitor at the neuromuscular junction. Selective antagonist of neuromuscular or neuronal nicotinic acetylcholine receptors. Not for sale in U.S.A.

Product Specific Literature References

Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI: G.C. Zafaralla, et al.; Biochemistry 27, 7102 (1988) Abstract
Synthesis of .alpha.-conotoxin SI, a bicyclic tridecapeptide amide with two disulfide bridges: illustration of novel protection schemes and oxidation strategies: M.C. Munson & G. Barany; JACS 115, 10203 (1993)
The alpha-conotoxins GI and MI distinguish between the nicotinic acetylcholine receptor agonist sites while SI does not: R.M. Hann, et al.; Biochemistry 33, 14058 (1994) Abstract
alpha-Conotoxins: nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads: J. L. Dutton & D. J. Craik; Curr. Med. Chem. 8, 327 (2001), (Review) Abstract
Alpha-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes: A. Nicke, et al.; Eur. J. Biochem. 271, 2305 (2004), (Review) Abstract
alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses: R.W. Janes; Curr. Opin. Pharmacol. 5, 280 (2005), (Review) Abstract

Further Categories Containing This Product:

Acetylcholine Receptors Other Products • Peptides

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