ALEXIS Biochemicals: D,L-threo-PDMP . hydrochloride

ALX-420-013

Revised 29-Jan-05

D,L-threo-PDMP . hydrochloride
SYNONYMS	D,L-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol . HCl PDMP
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Ceramides / Cerebrosides / Sphingolipids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-013-M005		5 mg	40.00 USD
ALX-420-013-M010		10 mg	70.00 USD

Product Specification

FORMULA:	C₂₃H₃₈N₂O₃ . HCl
MW:	390.6 . 36.5
CAS NUMBER:	73257-80-4
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in 100% ethanol, DMSO or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Useful tool to study the effects of cellular glycosphingolipid depletion. Blocks ceramide glucosylation by inhibiting UDP-glucose:ceramide glucosyl transferase (glucosylceramide synthetase). Has antitumor activity.

Product Specific Literature References

Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain: R.R. Vunnam & N.S. Radin; Chem. Phys. Lipids 26, 265 (1980) Abstract
Antitumor activity via inhibition of glycosphingolipid biosynthesis: J.-I. Inokuchi, et al.; Cancer Lett. 38, 23 (1987) Abstract
Preparation of the active isomer of 1-phenyl-2-decanoylamino-3- morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase: J. Inokuchi & N.S. Radin; J. Lipid Res. 28, 565 (1987) Abstract
Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells: J.-I. Inokuchi, et al.; J. Cell Physiol. 141, 573 (1989) Abstract
Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action: J.-I. Inokuchi, et al.; Cancer Res. 50, 6731 (1990) Abstract
Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts: K.-I. Uemura, et al.; J. Biochem. 108, 525 (1990) Abstract
N.S. Radin and J.-I. Inokuchi; Trends Glycosci. Glycotechnol. 3, 200 (1991)
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta 1083, 101 (1991) Abstract
Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway: A.G. Rosenwald; Biochemistry 31, 3581 (1992) Abstract
Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases: C.S. Rani, et al.; J. Biol. Chem. 270, 2859 (1995) Abstract; Full Text

Further Categories Containing This Product:

Antitumor Agents (Enzyme Inhibitors)

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