ALEXIS Biochemicals: Busulfan

ALX-400-048

Revised 06-Dec-07

Busulfan
SYNONYMS	1,4-Butanediol dimethanesulfonate
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (DNA Interaction & Gene Regulation)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-048-G010		10 g	20.00 USD

Product Specification

FORMULA:	C₆H₁₄O₆S₂
MW:	246.3
CAS NUMBER:	55-98-1
MERCK INDEX:	14: 1505
RTECS:	EK1750000
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white crystalline powder.
SOLUBILITY:	Soluble in acetone, 100% ethanol or DMSO; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	MAY BE CARCINOGENIC. VERY TOXIC. MAY BE TERATOGENIC.

Product Description

Antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5’-GA-3’ and, to a lesser extent, at 5’-GG-3’ sequences. Forms an intrastrand cross-link at the 5’-GA-3’ sequence, in addition to monoalkylation. Selectively induces normal human fibroblast senescence through Erk and p38 pathways.

Product Specific Literature References

DNA intrastrand cross-link at the 5’-GA-3’ sequence formed by busulfan and its role in the cytotoxic effect: T. Iwamoto, et al.; Cancer Sci. 95, 454 (2004) Abstract
Kinetic of genotoxic expression in the pharmacodynamics of busulfan: P. Morales-Ramirez, et al.; Arch. Med. Res. 37, 316 (2006) Abstract
Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway: V. Probin, et al.; Free Radic. Biol. Med. 42, 1858 (2007) Abstract

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